通过Lactobacillus rhamnosus补充在失脂性动物模型中改善脂质概况:系统性审查和元分析
Sungmin Chung1, Jiill Jeong1, Yeonwoo Park1
1Department of Food and Nutrition, Hanyang University, Seoul 04763, Republic of Korea.
Foods (Basel, Switzerland)
|February 13, 2026
概括
在临床前失脂症模型中,Lactobacillus rhamnosus和Lactobacillus casei益生菌显著降低了甘油三,总胆固醇和LDL胆固醇. 这些益生菌显示出作为管理失脂症的辅助营养策略的潜力.
科学领域:
- 微生物学和免疫学
- 心血管健康 心血管健康
- 营养科学 营养科学
背景情况:
- 脱脂症,标志着高甘油三 (TG),总胆固醇 (TC) 和低密度脂蛋白胆固醇 (LDL-C),是一个关键的心血管风险因素.
- 有限的证据表明,乳杆菌rhamnosus和乳杆菌casei的脂质调节作用.
研究的目的:
- 在临床前失脂症模型中系统地审查和元分析Lactobacillus rhamnosus和Lactobacillus casei的脂质调节作用.
- 评估这些益生菌作为管理失脂症的策略的潜力.
主要方法:
- 进行了一项系统性审查和元分析 (PROSPERO:CRD420251153531).
- 搜索了四个数据库,截至2025年7月,确定了12项研究.
- 使用SYRCLE工具评估偏差风险;进行随机效应元分析以估计标准化平均差异 (SMD) 和95%置信区间 (CI).
主要成果:
- 益生菌显著降低了TG (SMD: -1.38),TC (SMD: -0.85) 和LDL-C (SMD: -1.59) (所有p < 0.001).
- 没有观察到对高密度脂蛋白胆固醇水平的显著影响 (SMD: 0.18; p = 0.5044).
- 中等到实质性的异质性 (I2 = 36-51%) 和TC和LDL-C的潜在出版偏差需要谨慎解释.
结论:
- 在临床前的失脂症模型中,Lactobacillus rhamnosus和Lactobacillus casei显示出显著的降脂效应.
- 脂质降低可能由胆盐酸酶活性和通过肠肝轴产生的短链脂肪酸产生.
- L. rhamnosus显示出作为治疗失脂症的辅助营养策略的前景.
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