接受化疗的结肠癌患者的肠道微生物群和营养特征:一项纵向试点研究
Claire Han1,2, Daniel Spakowicz3, Diane Von Ah1,2
1Center for Healthy Aging, Self-Management and Complex Care, College of Nursing, The Ohio State University, Newton Hall, 1585 Neil Avenue, Columbus, OH 43210, USA.
Nutrients
|February 13, 2026
概括
化疗对结肠癌患者的饮食质量和肠道微生物群多样性产生负面影响. 更高的饮食质量可以防止这些负面影响,这表明在治疗期间营养和肠道健康之间存在联系.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 营养和肠道微生物群对于接受化疗的结肠癌患者的治疗耐受性和恢复至关重要.
- 这项试点研究调查了化疗期间饮食质量和便微生物群的变化.
研究的目的:
- 为了检查6个月化疗期间饮食质量和便微生物群的变化.
- 评估饮食质量与肠道微生物群多样性和种群之间的纵向关联.
主要方法:
- 评估了48名患有II-III期结肠癌的成年人,他们接受了基于5-甲的化疗.
- 用健康饮食指数 (HEI) 来衡量饮食质量,该指数来自3天的饮食回忆.
- 便样本进行了16S rRNA测序,用于微生物多样性和分类组合分析.
主要成果:
- 化疗期间饮食质量下降,纤维,水果,蔬菜和全谷物摄入量减少.
- 肠道微生物的α多样性下降,随着类 (Actinobacteriota下降; Bacteroidota,Proteobacteria增加) 和特定属 (Streptococcus下降,Escherichia增加) 的转变.
- 较高的基线饮食质量和改善与更大的微生物多样性和较低的蛋白质细菌丰富性有关,与有益的属性有积极的关联.
结论:
- 化疗与饮食质量和肠道微生物多样性的下降有关,以及分类学转变.
- 更高的饮食质量似乎可以防止化疗引起的微生物破坏,这表明双向关系.
- 针对营养和微生物群的干预措施需要对接受化疗的结肠癌患者进行进一步的研究.
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