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泰国植物提取物的脱糖酶抑制活性

Masashi Kawami¹, Ryoko Yumoto², Varaporn Buraphacheep Junyaprasert³

¹Department of Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women's University, Kyubanmachi, Koshien, Nishinomiya 668-8179, Japan.

|February 13, 2026

概括

泰国植物提取物Microcos tomentosa (MT80) 有效地抑制了关键的碳水化合物消化酶,如马尔塔酶,糖酶和三酶. 这种广泛的抑制表明,有可能调节饭后血糖峰值.

科学领域:

生物化学生物化学
药理学药理学是一个学科.
民族植物学民族植物学

背景情况:

肠道α-葡萄糖酶 (马尔塔酶,糖酶,三酶) 对于碳水化合物消化至关重要.
泰国药用植物以其生物活性而闻名,但缺乏系统的α-葡萄糖酶抑制研究.
以前的研究通常集中在单个酶上,主要是马尔塔酶.

研究的目的:

为了描述大鼠肠道α-葡萄糖酶的动力性质.
评估选择的泰国植物提取物对马尔塔酶,糖酶和三酶的抑制潜力.
为了识别具有广谱活性的植物性α-葡萄糖酶抑制剂.

主要方法:

小肠S9分数被准备用于隔离α-葡萄糖酶.
用葡萄糖氧化酶-过氧化酶方法量化了酶活性.
确定了动力参数,并对14种泰国植物提取物/化合物进行了抑制作用的选.

主要成果:

马尔塔酶显示了最高的基质亲和力 (最低的Km).
微科斯托门托萨 (MT80) 的80%乙醇提取物表现出对马尔塔酶,糖酶和三酶的一致抑制.
在250μg/mL时,MT80抑制了这些酶的10-60%;其他提取物显示有选择性的抑制.

结论:

MT80表现出对主要肠道α-葡萄糖酶的广泛抑制.
这表明MT80可能对管理食后葡萄糖水平有价值.
MT80是开发新型α-葡萄糖酶抑制剂的有希望的候选者.

关键词:

酶动力学酶动力学民族药理学民族药理学肠道失糖症是指肠道失糖症吃饭后的高血糖症 (hyperglycemia)传统的泰国药用植物.

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