在出生时体重非常低的婴儿中,产后生长失败的预测因子和风险评分
Nutcha Singhasem1, Gunlawadee Maneenil1, Anucha Thatrimontrichai1
1Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Nutrients
|February 13, 2026
概括
产后生长缺陷 (PGF) 影响了许多出生时体重非常低 (VLBW) 的婴儿. 关键的风险因素包括低出生体重,多胎和妊娠并发症,有助于早期识别和干预.
科学领域:
- 新生儿科学 新生儿科学
- 儿科生长与发展 儿科生长与发展
- 围产儿医学 围产儿医学
背景情况:
- 产后生长缺陷 (PGF) 是一个非常低出生体重 (VLBW) 婴儿的一个重大问题.
- 早期识别PGF风险的新生儿对于及时干预至关重要.
研究的目的:
- 为了确定与VLBW婴儿的PGF相关的因素.
- 开发一个预测模型,用于对PGF敏感的新生儿早期风险分层.
主要方法:
- 对VLBW婴儿 (2014-2024) 的回顾性队列研究.
- 使用2013年芬顿增长图定义的PGF.
- 采用多变量逻辑回归和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 在481名VLBW婴儿中,69.4%的婴儿经历了PGF.
- 有意义的预测因素包括出生体重<750g和750-1000g,多胎,妊娠引起的高血压,小水,产前皮质类固醇缺乏,配方奶粉/混合养.
- 开发的风险评分显示出良好的预测性表现 (AUC 0.736).
结论:
- 低出生体重 (<1000克),多胎儿,妊娠引起的高血压,小水,产前皮质类固醇的缺失,以及特定的养方法是PGF的关键预测因素.
- 衍生的风险评分可以帮助早期识别和针对性营养支持面临风险的VLBW婴儿.
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