维生素D在肌痛性脑筋炎/慢性疲劳综合征后COVID-19或疫苗接种:一个随机对照试验
Shinichiro Kodama1, Mitsuko Nakata2, Nafuko Konishi3
1Kodama Clinic, Hyogo 6650842, Japan.
Nutrients
|February 13, 2026
概括
维生素D替代疗法指南显著减少了维生素D缺乏症患者的肌痛性脑炎/慢性疲劳综合征 (ME/CFS) 症状. 这种方法改善了疫苗接种后综合征 (PVS) 或SARS-CoV-2感染后急性后续 (PASC) 患者的ME/CFS症状.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 神经学 神经学
背景情况:
- 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 可以表现为疫苗接种后综合征 (PVS) 或SARS-CoV-2感染的急性后续 (PASC).
- 以前的研究表明,在PVS相关的ME/CFS中,维生素D不足或缺乏的患病率很高.
- 这项研究研究了维生素D替代疗法对ME/CFS症状的改善.
研究的目的:
- 评估维生素D替代疗法在改善ME/CFS症状方面的有效性.
- 评估维生素D补充剂对ME/CFS患者血清25 (OH) 维生素D水平的影响.
- 为了比较综合维生素D指导组和对照组之间的结果.
主要方法:
- 一个开放的随机对照试验,涉及91名患有ME/CFS (PVS或PASC) 和血清25(OH) 维生素D<30ng/mL的参与者.
- 参与者被随机分配,在12周内接受全面指导的活性维生素D制剂或单独的活性维生素D制剂.
- 主要终点:从查到第12周的ME/CFS症状数量的变化.
主要成果:
- 与对照组 (-1.2) 相比,干预组显示出明显更大的平均症状减少 (-6.7).
- 干预组中血清25(OH) 维生素D水平显著增加 (18.6~27.1 ng/mL),但在对照组下降.
- 干预组中显著更高比例的参与者实现了<8个症状,满足了ME/CFS缓解的标准 (p < 0.001).
结论:
- 维生素D替代疗法指南有效地减少了ME/CFS症状在维生素D不足或缺乏的人.
- 该指导策略显著改善了ME/CFS患者的血清25(OH) 维生素D水平,无论是PVS还是PASC.
- 综合维生素D管理为经历PVS或PASC的ME/CFS患者提供了一个有前途的治疗方法.
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