相关实验视频
Updated: Feb 14, 2026
10:43
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
4.1K
在口腔癌模型中提[2,3-d]胺衍生物的抗癌潜力
Ivan Iliev1, Aleksandrina Nesheva2, Anelia Mavrova3
1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria.
Molecules (Basel, Switzerland)
|February 13, 2026
概括
新的锡诺皮里米丁化合物显示出针对口腔状细胞癌 (OSCC) 的选择性抗癌活性. 化合物5和6有效抑制癌细胞生长和存活,为向的OSCC疗法提供了一个有希望的途径.
科学领域:
- 药用化学 医学化学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔状细胞癌 (OSCC) 由于具有攻击性,经常复发和缺乏治疗选择性,因此存在重大治疗挑战.
- 目前对OSCC的治疗方式往往缺乏特异性,导致非目标效应和有效性有限.
研究的目的:
- 合成和评估一系列新型4-amino-2-替代四二二二二[2,3-d]胺衍生物的抗癌潜力,以对抗OSCC.
- 研究这些化合物的细胞毒性,抗增殖性和机械效应,对具有变异转移潜力的OSCC细胞系和正常角质细胞.
主要方法:
- 合成了七种四二二二二[2,3-d]胺衍生物.
- 在OSCC (HSC-3,SCC-9) 和HaCaT细胞系上使用细胞活力和克隆原性试验评估细胞毒性和抗增殖作用.
- 机理学研究,包括细胞循环分析和亡试验.
- 在ADME和药物相似性质的分析.
主要成果:
- 化合物5和6对OSCC细胞系,特别是高度转移的HSC-3细胞具有显著的选择性细胞毒性和抗增殖活性.
- 抗癌效应与S相细胞循环停止,诱导细胞亡以及动因细胞骨的破坏有关.
- 在 silico 研究表明,最强大的衍生品具有有利的类似药物的特性.
结论:
- 四二二二二二烯衍生物代表了开发针对口腔状细胞癌的向治疗的有希望的支架.
- 化合物5和6显示出作为化合物的潜力,可用于OSCC治疗的进一步优化和体内研究.
相关概念视频
01:11Oral Cavity
3.2K
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.2K
02:58Cell Potential and Free Energy
46.8K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.8K
00:52Potential Energy
42.9K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.9K
03:02Standard Electrode Potentials
50.5K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.5K
01:21The Resting Membrane Potential
143.3K
Overview
143.3K
01:16Electric Potential and Potential Difference
5.8K
Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
5.8K