具有抗血栓和抗氧化活性的二次代谢物来源于Cordyceps cicadae
Xingze Hu1, Guisheng Wang1, Tao Chen1
1School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
Molecules (Basel, Switzerland)
|February 13, 2026
概括
这项研究从Cordyceps cicadae中分离出新型化合物,显示出显著的抗血栓和抗氧化活性. 这些发现在科学上支持了这种虫病原菌的传统医疗用途.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
背景情况:
- 皮草 (Cordyceps cicadae) 是一种传统的中医药,具有多样化的治疗应用.
- 它的民族药理学用途需要对其生物活性成分进行科学验证.
- 了解化学成分是释放其药用潜力的关键.
研究的目的:
- 从Cordyceps cicadae中分离和描述生物活性化合物.
- 评估分离化合物的抗血栓和抗氧化活性.
- 提供科尔迪塞普斯 (Cordyceps cicadae) 的传统医疗应用的科学证据.
主要方法:
- 使用各种色谱技术进行化合物隔离.
- 通过综合光谱分析 (1D/2D NMR,HRESIMS),ECD计算,DP4+分析和修改的莫舍尔方法进行结构阐明.
- 采用斑马鱼模型和抗氧化剂试验 (DPPH激素清理) 的体外抗血栓试验.
主要成果:
- 确定了一种新的黄类化合物 (quercetin-3-O-β-D-methylglucopyranoside) 和一种新的二碳酸衍生物 (cicadae acid),以及三种已知的黄类化合物.
- 所有分离的化合物 (1-5) 在斑马鱼模型中在20μM时表现出显著的抗血栓作用.
- 化合物1-4表现出强烈的抗氧化活性,在DPPH测定中IC50值在12.81±3.42到20.16±2.64μM之间.
结论:
- 这项研究成功地鉴定和描述了Cordyceps cicadae的新型和已知的化合物.
- 孤立的黄酸和二糖酸具有显著的抗血栓和抗氧化特性.
- 这些发现证实了Cordyceps cicadae的传统用途,并突出了它在治疗血栓塞和与氧化压力相关的疾病方面的潜力.
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