纤维菌素是口腔癌和乳腺癌共同的可能治疗标
Silvia Pomella1,2, Roberto Bei1, Ombretta Melaiu1
1Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
International journal of molecular sciences
|February 13, 2026
概括
表皮-介质细胞过渡 (EMT) 驱动癌症转移和乳腺癌 (BC) 和口腔状细胞癌 (OSCC) 的免疫逃避. 纤维菌素 (FN) 是一种关键的EMT基因,与两种癌症中的免疫抑制性巨细胞有关,这表明FN抗剂是潜在的治疗方法.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 表皮-介质细胞过渡 (EMT) 对于表皮修复至关重要,但在乳腺癌 (BC) 和口腔状细胞癌 (OSCC) 等恶性瘤中驱动癌症的进展,转移和免疫逃逸.
- 了解EMT与瘤免疫微环境之间的相互作用对于确定新的治疗策略至关重要.
- 失调的EMT有助于OSCC和BC的攻击性.
研究的目的:
- 研究OSCC和转移性BC中EMT签名和免疫细胞透之间的关系.
- 确定与EMT和免疫反应相关的OSCC和BC的常见或独特的预后标志物和治疗点.
- 探索特定的EMT相关基因在这些癌症中的免疫调节中的作用.
主要方法:
- 对OSCC和转移性BC的公开可用的转录基因数据集的分析.
- 识别参与EMT的编码基因,与免疫细胞特征有很强的相关性.
- 相关性分析,签名重叠的确定,并使用独立数据库进行验证.
主要成果:
- 与EMT相关的基因表达与OSCC和BC的免疫抑制和前瘤巨细胞有很强的相关性.
- 编码纤维素蛋白 (FN) 的 *FN1* 基因,在两种瘤类型中都成为一种常见的 EMT 基因.
- 与正常组织相比,OSCC和BC组织中观察到较高的FN蛋白水平,支持其在癌症进展中的作用.
结论:
- 纤维素 (FN) 在促进瘤入侵,转移和阻碍OSCC和BC的抗瘤免疫反应方面发挥着重要作用.
- 通过对抗剂向FN可能是治疗OSCC和BC的有前途的辅助疗法.
- 该研究确定了FN作为这些独特的上皮质恶性瘤的潜在常见治疗标.
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