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NADCdb:一个联合转录基因数据库,用于艾滋病毒阳性个体的非艾滋病定义癌症研究
Jiajia Xuan1, Chunhua Xiao1, Runhao Luo1
1MOE Key Laboratory of Tumor Molecular Biology and State Key Laboratory of Bioactive Molecules and Druggability Assessment, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
International journal of molecular sciences
|February 13, 2026
概括
非艾滋病确定的癌症 (NADCs) 是艾滋病毒感染者 (PLWH) 的一个主要问题. NADCdb集成了转录组数据,以识别23个NADC的关键调节剂和生物标志物,帮助病理探索.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 非艾滋病确定的癌症 (NADCs) 是艾滋病毒感染者 (PLWH) 的主要死亡原因.
- 有限的临床样本和数据隐私阻碍了NADC研究.
- 了解NADC的致病性对于改善PLWH的结果至关重要.
研究的目的:
- 系统地识别23个NADC的关键调节剂和生物标志物,使用集成的转录基因数据.
- 开发NADCdb,一个全面的数据库和NADC研究的分析平台.
- 探索免疫抑制,炎症,病毒感染和HIV在NADC发育中的相互作用.
主要方法:
- 从12,486名PLWH和癌症患者的转录组数据的联合分析.
- 开发NADCdb,包括风险评估 (rNADC),驾驶员识别 (dNADC) 和免疫生物标志物发现 (iPredict) 的模块.
- 使用双向渐进回归,逻辑建模,随机森林和条件推理树进行分析.
主要成果:
- 创建了NADCdb,整合了23个NADC的数据和分析框架.
- rNADC模块对21种NADC进行了分层风险分类;dNADC以>75%的准确度确定了致病驱动因素 (与艾滋病毒相关的清晰细胞细胞癌>90%).
- 对于16个NADC,iPredict确定了1905个免疫生物标志物,并对关键决定因素进行了多维分析.
结论:
- NADCdb为NADC的病理探索提供了一个新的,集中的资源.
- 该数据库提供了有价值的分析框架和对NADC病变发生的见解.
- 促进科学探索和潜在的治疗标的鉴定在PLWH中NADCs.
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