在免疫检查点抑制剂相关炎的诊断和监测中的尿路化学物质
Francisco Gomez-Preciado1,2, Laura Martinez-Valenzuela1, Paula Anton-Pampols3
1Department of Nephrology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), 08907 Hospitalet de Llobregat, Barcelona, Spain.
International journal of molecular sciences
|February 13, 2026
概括
包括CXCL9和CXCL10在内的新型尿路生物标志物显示出有望用于诊断和监测由免疫检查点抑制剂 (ICI) 引起的急性间歇性炎 (AIN). 这些标志物有助于评估治疗后功能恢复.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是重要的癌症治疗方法,但可能导致与免疫相关的不良事件,特别是急性间歇性炎 (ICI-AIN).
- 准确的诊断和ICI-AIN的监测对于患者的管理和功能保护至关重要.
- 识别非侵入性生物标志物对于ICI-AIN的早期检测和有效后续行动至关重要.
研究的目的:
- 确定新的尿路生物标志物,用于诊断和监测与免疫检查点抑制剂 (ICI) 相关的急性间歇性炎 (AIN).
- 研究可溶性PD-1,PD-L1,PD-L2,化学激素 (CXCL5,CXCL9,CXCL10,CXCL11,CCL2,CCL3,CCL5) 和细胞激素 (IL-6,IL-12p70) 在ICI-AIN病原发生中的作用.
- 评估生物标志物水平与治疗后功能恢复之间的相关性.
主要方法:
- 一种Luminex试验用于测量ICI-AIN,非ICI AIN和急性管状缩 (ATN) 患者的特定生物标志物的尿液水平.
- 在ICI-AIN患者的诊断和随访期间分析了生物标志物度.
- 在患者组之间进行了统计比较,并评估了与功能恢复的相关性.
主要成果:
- 在ICI-AIN患者中,与ATN患者相比,尿液中的CXCL5,CXCL9,CXCL10,CXCL11,CCL5和IL-6显著升高.
- 在ICI-AIN患者和非ICI AIN患者中,CXCL5,CXCL9,CXCL10,CXCL11和CCL5也更高.
- 在治疗后,ICI-AIN患者的CXCL9,CXCL10,CXCL11和CCL2水平下降,CXCL9和CXCL10的减少与改善的功能恢复相关.
结论:
- 尿路CXCL5,CXCL9,CXCL10,CXCL11,CCL5和IL-6显示出作为ICI-AIN的非侵入性生物标志物的潜力.
- 治疗后CXCL9,CXCL10,CXCL11和CCL2的水平降低表明它们在监测患者康复中的有用性.
- 这些生物标志物可以促进精确的患者监测,并改善ICI-AIN的管理策略.
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