与COVID-19住院患者的血清calprotectin与高维血清蛋白质组模式的关系
Åsa Parke1,2, Benedikt Strunz2, Puran Chen2
1Department of Infectious Diseases, Karolinska University Hospital, 141 57 Stockholm, Sweden.
International journal of molecular sciences
|February 13, 2026
概括
卡尔普罗丁是一种严重的COVID-19和败血症的潜在生物标志物. 在COVID-19患者中,高蛋白水平表明中性粒细胞驱动的炎症和疾病严重程度.
科学领域:
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
- 传染性疾病 传染性疾病
背景情况:
- 卡尔普罗丁是一种严重的COVID-19和败血症的潜在生物标志物.
- 在这些条件下,calprotectin的生物作用需要进一步研究.
研究的目的:
- 为了研究COVID-19患者血清calprotectin和循环蛋白质之间的关联.
- 探索calprotectin作为病毒性败血症生物标志物的作用.
主要方法:
- 对160名住院的成年COVID-19患者进行了观察性研究.
- 血清calprotectin通过度测定测量.
- 使用Olink Explore 1536平台进行蛋白质组学分析.
主要成果:
- 在严重与中度COVID-19中,中位数calprotectin水平较高.
- 与中性粒细胞为中心的炎症性蛋白质特征相关的calprotectin.
- 在calprotectin和S100A12.12之间发现的最强相关性.
结论:
- 蛋白与COVID-19疾病的严重程度有关.
- 高的calprotectin反映在病毒性败血症中中性粒细胞介导的高炎症.
- 这些发现支持calprotectin作为中性粒细胞驱动炎症的生物标志物.
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