自然生物活性化合物向FABP4在脂肪生成和肥胖中:来自体外和体外研究的证据
Jan Sobczyński1, Filip Nowaczyński1,2, Katarzyna Smolińska3
1Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Lublin, Chodźki St. 1, 20-093 Lublin, Poland.
International journal of molecular sciences
|February 13, 2026
概括
自然化合物可以调节脂肪酸结合蛋白4 (FABP4) 以对抗与肥胖相关的代谢衰退. 本次审查强调了针对FABP4的植物和非植物来源,以改善代谢健康.
科学领域:
- 代谢健康 代谢健康
- 肥胖问题研究研究
- 营养保健品 营养保健品
背景情况:
- FABP4 (脂肪酸结合蛋白4) 将肥胖与炎症和胰岛素抵抗联系在一起.
- 在脂肪细胞和巨细胞中,FABP4调节核受体信号传递和炎症通路.
- 失调的FABP4有助于脂肪重塑和全身代谢下降.
研究的目的:
- 审查针对FABP4.4的天然生物活性化合物的临床前证据.
- 总结调节FABP4表达和脂肪生成程序的化合物.
- 探索FABP4作为代谢障碍的治疗节点.
主要方法:
- 关于脂肪生成和饮食诱导的肥胖模型的临床前研究的综述.
- 来自细胞培养 (3T3-L1/OP9脂肪细胞) 和动物研究的数据分析.
- 包括替代模型和非植物衍生化合物.
主要成果:
- 许多植物提取物和植物化学物质在mRNA和蛋白质水平下调FABP4.
- 观察到的效应包括抑制关键的脂肪生成信号通路 (PPARγ,C/EBPα,SREBP1c).
- 天然化合物改善了新陈代谢结果,如减轻体重增加,脂肪细胞缩,肥胖症,改善了血清脂质.
结论:
- FABP4是代谢性疾病的可行的治疗标,具有来自植物和非植物自然来源的潜力.
- 关键的翻译挑战包括标准化,生物可用性和临床验证.
- 未来的研究应该专注于具有良好的特征的化合物,有针对性的输送和强大的临床试验.
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