氧化应激和内皮功能障碍在患有高血压脏病患者:地中海饮食的作用
Luca Salomone1, Danilo Menichelli2, Irene Azzara1
1Nephrology Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
International journal of molecular sciences
|February 13, 2026
概括
患有高血压脏病的基本高血压患者表现出较高的内血管抵抗,与增加的氧化应激和受损的内皮功能有关. 在这些患者中,更严格地遵守地中海饮食可能会减少NOX2相关的氧化应激.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 营养科学 营养科学
背景情况:
- 基本高血压是慢性病 (CKD) 的主要驱动因素,经常导致高血压脏病.
- 高血压性病包括血管硬化和高内血管抵抗,可通过抗性指数 (RRI) 测量.
- 氧化应激和内皮功能障碍是导致CKD进展的关键因素,地中海饮食 (MD) 可能具有保护作用.
研究的目的:
- 在患有基本高血压和高血压脏病的患者中,研究RRI,氧化应激标志物,内皮功能和遵守地中海饮食之间的关系.
- 探索这些因素与被研究人群中估计的淋巴细胞过率 (eGFR) 之间的关联.
主要方法:
- 这是一项涉及99名患有基本高血压,高血压,CKD G1-G4 (KDIGO) 阶段的患者的横截面研究.
- 评估包括氧化应激 (sNOX2-dp,H2O2) 和内皮功能 (NO) 的实验室测试,RRI的脏超声波,以及MD坚持的PREDIMED问卷.
- 进行了统计分析,以确定RRI,氧化应激,内皮功能,MD附着性和eGFR之间的相关性.
主要成果:
- 在RRI和氧化应激标志物 (sNOX2-dp,H2O2) 之间发现了显著的正相关性,在RRI和氧化 (NO) 之间发现了显著的反相关性.
- 观察到RRI和MD坚持 (PREDIMED分数) 之间的反向关联趋势,以及RRI和eGFR之间的显著反向相关性.
- 较高的MD坚持与较低的NOX2-介导氧化应激 (sNOX2-dp) 有显著的相关性.
结论:
- 在高血压性脏病中,内血管阻力升高与氧化应激增加,内皮功能降低和EGFR降低有关.
- 坚持地中海饮食显示出与减少NOX2介导氧化应激的潜在联系.
- 这些发现表明,饮食在高血压脏病的微循环功能障碍管理中起着作用,需要在更大的纵向研究中进一步调查.
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