皮亚可可斯减轻LPS/D-Galactosamine诱导的小鼠急性肝衰竭:一个整合性的探索性研究,结合网络药理学和体内验证
Peihua Wen1, Xinru Jian1, Xiaoyu Ren1
1School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430048, China.
International journal of molecular sciences
|February 13, 2026
概括
波利亚子提取物通过减少炎症和亡来保护急性肝衰竭 (ALF) 的承诺. 这项研究结合了网络药理学和动物实验,以探索其肝脏保护机制.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 传统中国医药 传统中国医药
背景情况:
- 急性肝衰竭 (ALF) 是一种严重的疾病,治疗选择有限.
- 作为中国传统医药中的一种,Poria cocos已知具有抗炎和肝脏保护性质.
- 它在ALF中的作用需要进一步调查.
研究的目的:
- 为了研究Poria cocos对大鼠的脂多糖/D-银胺 (LPS/D-GalN) 诱导的ALF的保护作用.
- 通过网络药理学,分子对接和体内实验来阐明潜在机制.
主要方法:
- 一种结合网络药理学,分子对接和体内实验的综合方法.
- 在诱导ALF之前,老鼠先用Poria cocos提取物进行预处理.
- 评估包括生存率,血清标志物 (ALT,AST,TBil,INR),组织病理学和分子标志物表达.
主要成果:
- 网络药理学确定了关键的生物活性成分,点和途径 (炎症,亡,PI3K/AKT).
- 分子对接支持 Poria cocos 组件和目标之间的相互作用.
- 在体内研究表明,Poria cocos预治疗改善了生存率,减少了肝损伤,并调节了炎症/亡标志物 (PI3K,AKT1,NF-κB,TNF-α,Caspase-3).
结论:
- 在老鼠中,Poria cocos对LPS/D-GalN诱导的ALF表现出显著的肝保护作用.
- 该机制可能涉及炎症和亡途径的多目标调节,特别是PI3K/AKT信号传递.
- 波利亚可可斯代表了ALF的潜在治疗剂.
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