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人体便移植修改了肠道微生物群,但并没有改变结肠癌患者的代谢物
Katarzyna Unrug-Bielawska1, Zuzanna Sandowska-Markiewicz1, Ewelina Kaniuga1
1Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.
International journal of molecular sciences
|February 13, 2026
概括
便微生物种移植 (FMT) 在结直肠癌模型中重塑了肠道微生物,但仅仅改变了瘤生长. 在一些模型中,FMT增强了化疗疗效,这表明微生物群介导的治疗调节.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在结直肠癌 (CRC) 的发展和治疗反应中起着至关重要的作用.
- 便微生物群移植 (FMT) 是一种潜在的策略,可以重新平衡肠道微生物并改善治疗结果.
研究的目的:
- 研究人类便移植对肠道微生物群,代谢物,瘤生长以及结直肠癌患者衍生异种移植 (CRC PDX) 模型中的化疗疗效能的影响.
主要方法:
- 在NSG小鼠中使用了四个CRC PDX模型.
- 进行了16S rRNA测序,用于肠道微生物群的概况.
- 使用质谱分析分析了短链脂肪酸 (SCFA) 和氨基酸 (AAs).
- 进行便微生物群移植 (FMT) 和FOLFOX化疗.
主要成果:
- FMT显著改变了肠道微生物群的组成,增加了α-多样性和修改β-多样性.
- 单独使用FMT并没有影响瘤生长.
- 在所有模型中,FOLFOX化疗抑制了瘤的进展.
- 在四个CRC PDX模型中,FMT在两种模型中增强了FOLFOX的疗效.
- 尽管存在显著的微生物群转移,但FMT对便SCFA和AA的影响很小.
结论:
- 在CRC PDX模型中,便微生物群移植诱导了显著的肠道微生物群重塑.
- 单独使用FMT不会影响瘤生长,但在特定模型中可以提高FOLFOX化疗的疗效.
- 这些发现支持在结直肠癌中通过微生物群调节化疗结果的作用.
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