严重的COVID-19与严重的COVID-19中的细胞因子动态. 感冒老年患者:一个前性比较研究
Mihai Aronel Rus1, Adina Huțanu2,3, Daniel Corneliu Leucuța4
1Department of Infectious Diseases, "Iuliu Hatieganu" University of Medicine and Pharmacy, Iuliu Moldovan Street, no 23, 400348 Cluj-Napoca, Romania.
住院患有COVID-19的老年患者的初始细胞因子水平 (IL-6,IL-10,CXCL10) 比A型流感 (FluA) 高. 干白素-6 (IL-6) 在这些严重的呼吸道感染中预测了呼吸支持的需求.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 老年病的医生 老年病的医生
背景情况:
- COVID-19和流感A (FluA) 在老年人中引起严重的呼吸系统疾病,涉及细胞因子失调.
- 有限的直接比较数据存在于这些感染住院的老年人中细胞因子概况.
研究的目的:
- 为了比较COVID-19住院的老年患者的细胞因子动态,与FluA相比.
- 评估细胞因子对呼吸衰竭和非侵入性通风 (NIV) 的预后价值.
主要方法:
- 对60岁以上因COVID-19或流感A而导致呼吸衰竭的住院成年人进行前性队列研究.
- 血清细胞因子 (IL-1β,IL-6,IL-10,IL-17A,IL-34,MCP-1,CXCL10) 在使用Luminex®的第1天和第5天进行测量.
- ROC分析和后勤回归评估了细胞因子与NIV的关联.
主要成果:
- 与流感A患者 (n=44) 相比,COVID-19患者 (n=39) 的第1天IL-6,IL-10和CXCL10较高.
- 在两组中,细胞因子水平在第五天下降.
- 基线IL-6独立预测NIV (aOR3.02);较高的MCP-1与减少NIV需求有关.
结论:
- 显而易见的早期细胞因子概况使COVID-19与老年患者的流感不同,尽管它们在第5天汇聚在一起.
- IL-6是呼吸系统恶化的显著早期预测因素,需要NIV.
- 在严重的呼吸道感染中,MCP-1可能表明受调节的先天免疫反应.
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