肝细胞FOXA3的损失改善了超脂性LDLR缺乏的小鼠中的MASH和动脉样硬化

Hui Wang1,2, Shuwei Hu1, Jiayou Wang1

  • 1Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.

概括

在标准小鼠中,肝脏叉头盒蛋白A3 (FOXA3) 的损失没有影响代谢功能障碍相关的脂肪肝炎 (MASH). 然而,它在高脂肪饮食模型中保护MASH,高脂血症和动脉样硬化.

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