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从风险到根源:儿童肥胖的多因素病原发生
Vasile Valeriu Lupu1, Alin Horatiu Nedelcu1, Elena Jechel1
1Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
International journal of molecular sciences
|February 13, 2026
概括
儿童肥胖是一个日益严重的全球流行病,受遗传学,环境和生活方式的影响. 本综述综合了关于其复杂原因和基于证据的干预措施的当前研究,以获得更好的儿童健康结果.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 全球儿童肥胖率正在上升,这对公众健康构成了重大挑战.
- 儿童肥胖的发展涉及遗传,表观遗传,环境,营养,心理和内分泌因素之间的复杂相互作用.
- 现有的研究往往侧重于特定的机制,需要进行全面的综合.
研究的目的:
- 为儿童肥胖的最新病理生理学原则提供全面的叙事审查.
- 强调儿童肥胖研究中的临床相关方面和新发现.
- 综合遗传,表观遗传,环境和精神病学决定因素的证据,并讨论基于证据的治疗方法.
主要方法:
- 采用了一个叙事审查方法.
- 文献搜索侧重于儿科肥胖机制和干预措施的最新进展.
- 研究的选择是基于它们与遗传,表观遗传,环境和心理因素的相关性.
主要成果:
- 儿童肥胖是多因素的,涉及各种决定因素之间的复杂相互作用.
- 突出了新的病理生理学见解及其临床影响.
- 讨论了基于证据的减轻可修改风险因素的策略.
结论:
- 对于有效的干预,全面了解儿科肥胖的复杂机制至关重要.
- 将最近的发现纳入临床实践可以帮助限制儿童肥胖的发病率和并发症.
- 扩大科学基础的干预措施对于改善受影响儿童的长期健康结果至关重要.
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