脂肪组织和癌:一个瘤代谢和内分泌联盟
Matías Ferrando1, Daiana Lorena Moya Morales1, Leonardo Rafael Romeo1,2
1Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Centro Científico y Tecnológico Mendoza, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza M5500, Argentina.
International journal of molecular sciences
|February 13, 2026
概括
清细胞细胞癌 (ccRCC) 改变了附近的人类脂肪组织 (hRAN),导致脂肪细胞分化,色和乳酸生产增加. 这突显了ccRCC瘤和 stromal脂肪细胞之间的代谢伙伴关系.
科学领域:
- 在瘤学瘤学.
- 代谢研究的研究.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 癌症的进展涉及代谢重编程和微环境相互作用.
- 清细胞细胞癌 (ccRCC) 呈现与相邻脂肪细胞的交叉声.
- 脂肪细胞是ccRCC中丰富的 stromal 组成部分.
研究的目的:
- 研究ccRCC对人类脂肪组织 (hRAN) 的影响.
- 分析暴露于ccRCC的hRAN中的脂肪基因表达,分化,色,新陈代谢和激素受体的变化.
- 阐明ccRCC和脂肪组织之间的动态关系.
主要方法:
- 人体逆皮质脂肪组织碎片与来自ccRCC瘤 (T-CM) 或细胞 (Tc-CM) 的条件介质进行了化.
- 分析包括脂肪基因,分化/色标志物 (PLIN1,HSL,PGC1α,PPARγ,UCP1),代谢参数和类固醇激素受体 (ERα,ERβ,AR,PR).
- 评估了乳酸分泌和脂肪细胞形态.
主要成果:
- 在hRAN中,T-CM和Tc-CM改变了阿迪波内克丁和莱普的表达.
- 脂肪细胞分化和色标志物 (PLIN1,HSL,PGC1α,PPARγ,UCP1) 被显著影响.
- 脂肪细胞的尺寸减少 (脱差),FABP4和MCT1表达增加,乳酸分泌量增加.
- 雌激素受体 (ERα,ERβ) 被上调,而雄激素和孕激素受体保持不变.
结论:
- 在ccRCC中代谢重编程会诱导邻近脂肪组织的显著适应性变化.
- 在hRAN中脱差,色,改变的脂肪基因形状和增加的乳酸生成反映了瘤诱导的代谢压力.
- 这项研究提供了ex vivo证据,证明了ccRCC和人类脂肪组织之间的动态代谢伙伴关系.
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