在黑色素瘤中循环瘤DNA:检测,临床应用和与新兴技术的整合方面的进展
Nicole Charbel1, Joe Rizkallah2, Mark Nicolas Bal1
1Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.
International journal of molecular sciences
|February 13, 2026
概括
循环瘤DNA (ctDNA) 显示出作为黑色素瘤检测,复发风险和治疗监测的非侵入性生物标志物具有前途. ctDNA技术的进步旨在提高对早期疾病的敏感性,并指导个性化治疗.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 生物标志物发现发现
背景情况:
- 循环瘤DNA (ctDNA) 是黑色素瘤的一个新兴的非侵入性生物标志物.
- 它反映了实时瘤遗传学,并有助于各种临床应用.
研究的目的:
- 审查当前关于黑色素瘤中ctDNA的证据.
- 总结其生物学,检测方法和临床实用性.
- 概述临床实施的挑战和未来方向.
主要方法:
- 关于黑色素瘤中ctDNA的当前科学文献的综述.
- 分析ctDNA在早期和晚期疾病中的作用.
- 讨论新兴的检测技术和整合策略.
主要成果:
- ctDNA有助于检测最小残留疾病,复发,瘤负担和治疗反应.
- 手术后ctDNA阳性与早期黑色素瘤复发风险相关.
- 在晚期黑色素瘤中,ctDNA监测治疗反应和耐药性.
结论:
- 在不同疾病阶段的黑色素瘤管理中,ctDNA具有显著的潜力.
- 克服诸如低脱落率和平台可变性等局限性至关重要.
- 将ctDNA与其他技术集成在一起,将提高黑色素瘤的精准医学.
相关概念视频
Applications of GIS: Disaster Management and Emergency Response
545
Geographic Information System (GIS) technology is essential for risk identification, action prioritization, and resource optimization in critical situations like flooding and earthquakes. By integrating spatial and demographic data, GIS provides a comprehensive framework for emergency response.GIS integrates data layers, like rainfall intensity, topography, elevation profiles, and river levels, to model high-risk flood zones. These layers assess areas susceptible to flooding based on their...
545
Application of Integration: Problem Solving
107
The process of breathing involves the periodic intake and expulsion of air, known as the respiratory cycle, which typically lasts about five seconds. Modeling the volume of air inhaled into the lungs as a function of time provides insight into both the dynamics and efficiency of pulmonary ventilation. This volume is determined by integrating the airflow rate over time, which captures the cumulative effect of air entering the lungs.Sinusoidal Model of AirflowAirflow during respiration is not...
107
Applications of Integration to Find Centers of Mass
86
Rotational equilibrium provides a natural framework for defining the center of mass of a system. For a plank balanced on a pivot with two unequal masses, equilibrium is achieved when the net torque about the pivot is zero. Torque is defined as the product of a force and its perpendicular distance from the pivot. When the torques due to all forces cancel, the pivot coincides with the center of mass of the system.For a system composed of several discrete point masses, the center of mass lies at...
86
Applications of Integration to Find Blood Flow
62
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
62
Applications of Integration to Find Hydrostatic Pressure
103
Hydrostatic force is a fluid's total force at rest on a surface. For a horizontal surface submerged at a fixed depth, the pressure is constant and calculated as the product of fluid density, gravitational acceleration, and depth. In the case of a vertical dam wall submerged in water, this force is not evenly distributed due to the increasing pressure with depth. This variation arises from the cumulative weight of the water above each point. Integration is used to account for the continuous...
103
Applications of Integration to Find Consumer Surplus
66
In microeconomics, consumer surplus represents the economic gain that consumers experience when they purchase a good or service for less than the highest price they are willing to pay. This surplus arises from the characteristics of the demand function, which links the quantity of a good to the price consumers are willing to pay. As the quantity of a good increases, the price that consumers are willing to pay for each additional unit typically decreases, resulting in a downward-sloping demand...
66


