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神经退行性疾病中的Nrf2-激活天然化合物:针对氧化应激和蛋白质聚合

Lucia Chico¹, Erika Schirinzi², Linda Balestrini¹

¹Laboratori Aliveda S.r.l., 56042 Crespina Lorenzana, Italy.

International journal of molecular sciences

|February 13, 2026

概括

激活核因素红色素2相关因子2 (Nrf2) 的天然化合物显示出神经保护的前景. 这些诱导Nrf2的营养品通过解决氧化应激和蛋白质聚合,提供了多目标方法来对抗神经退行性疾病 (NDs).

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物化学生化学

背景情况:

神经退行性疾病 (NDs) 是一个主要的全球健康问题,其特点是复杂的机制,包括氧化应激,蛋白质聚合和神经炎症.
目前对ND的治疗主要是症状性,缺乏疾病修饰能力.
核因子红色素2相关因子2 (Nrf2) 是一个关键的转录因子,调节细胞抗氧化剂和蛋白质稳定路径,其失调与ND病变产生有关.

研究的目的:

审查氧化应激和蛋白质聚合在阿尔茨海默氏症,帕金森病,ALS和亨廷顿病等主要ND中的作用.
检查来自植物,真菌和海洋来源的天然化合物的神经保护潜力.
突出Nrf2激活作为这些天然化合物的治疗作用背后的机制的重要性.

主要方法:

文献综述侧重于氧化应激,蛋白质聚合和NDs中的Nrf2信号.
对研究自然化合物对神经保护作用的研究进行分析.
综合有关作用机制的信息,特别是Nrf2激活和蛋白质稳定维护.

主要成果:

天然生物活性化合物表现出与NDs相关的抗氧化,抗聚合和抗丧性质.
Nrf2信号通路的激活是这些化合物通过神经保护的常见机制.
Nrf2不仅在氧化还原调节中起着至关重要的作用,而且在维持蛋白质稳定中也起着至关重要的作用.

结论:

激活Nrf2的天然化合物代表了NDS中神经保护的有前途的多目标药物.
这些营养药可以作为传统疗法有价值的补充策略.
向Nrf2为开发神经退行性疾病的疾病修饰治疗提供了潜在的途径.

关键词:

Nrf2 没有任何问题.菌是一种真菌.海洋生物海洋生物神经退行症的神经退行症氧化应激是一种氧化应激.植物多醇是一种植物多醇.蛋白质聚合蛋白质的聚合物

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