在自身免疫性疾病中Triptolide的分子机制和治疗潜力:进步和挑战
Junning Zhang1, Fangying Huang2, Yujiao Xu2
1Joint Research Center of Occupational Medicine and Health, Institute of Grand Health, Hefei Comprehensive National Science Center, Anhui University of Science and Technology, Hefei, P. R. China.
The American journal of Chinese medicine
|February 13, 2026
概括
ptolide (TP) 通过抑制炎症和调节免疫细胞来治疗自身免疫性疾病具有前景. 然而,其临床使用受到显著毒性的阻碍,促使人们研究更安全的输送和修改策略.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 全球自身免疫性疾病的发病率正在上升,需要新的治疗药物.
- 来自*Tripterygium wilfordii*的托利德 (TP) 具有强大的免疫抑制和抗炎性质.
- 由于其多方面的机制,TP具有治疗各种自身免疫疾病的潜力.
研究的目的:
- 审查Triptolide在自身免疫性疾病中的药理机制.
- 评估Triptolide在自身免疫性疾病中的治疗潜力.
- 总结Triptolide安全临床转换的毒理学挑战和策略.
主要方法:
- 对药理学机制的系统审查.
- 对免疫细胞和免疫通路的治疗作用的分析 (例如,T/B细胞激活,细胞因子抑制,NF-κB,JAK/STAT,PI3K/Akt).
- 评估缓解三类毒性的策略.
主要成果:
- TP抑制T和B细胞激活,平衡T辅助17/调节性T细胞,并抑制促炎性细胞因子.
- TP调节关键信号通路 (NF-κB,JAK/STAT,PI3K/Akt),调节氧化应激,并影响肠道微生物群.
- 肝脏,脏和生殖器官的显著剂量和时间依赖性毒性限制了TP的临床应用.
结论:
- ptolide通过各种机制证明了对自身免疫性疾病的显著治疗潜力.
- 缓解TP的全身毒性对于其安全的临床应用至关重要.
- 结构修改和先进的传递系统等策略是改善TP治疗指数的关键.
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