结合ER/PR共阳性增强了子宫内膜癌分子亚型内的预后分层
Ruxue Han1, Yang Chen1, Shuiqing Xu1
1Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
结合雌激素受体 (ER) 和孕激素受体 (PR) 的共同积极性显著改善了子宫内膜癌 (EC) 的生存预测,特别是在无特异分子谱 (NSMP) 亚型中.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 癌症基因组学 癌症基因组学
背景情况:
- 子宫内膜癌 (EC) 呈现出多种分子亚型,预后不同.
- 无特异分子形状 (NSMP) 亚型在预后上是异质的,需要精确的风险分层.
- 雌激素受体 (ER) 和孕激素受体 (PR) 表达是EC的关键生物标志物,但它们在分子亚型中的综合预后价值需要进一步阐明.
研究的目的:
- 调查结合ER/PR表达模式在子宫内膜癌的预后意义.
- 具体评估ER/PR状态对不同分子亚型内的特定疾病生存率 (DSS) 和无进展生存率 (PFS) 的影响,重点关注NSMP组.
主要方法:
- 对388名EC患者进行了回顾性分析,使用了基于下一代测序的分子分类.
- 对ER/PR表达的免疫组织化学评估,将患者分为共阳性 (coP),共阴性或异调组.
- 多变量考克斯回归和一致性指数 (C指数) 分析,以评估生存结果.
主要成果:
- 独立地预测ER/PR共阳性在EC总体上改善了DSS (HR=0.143,p<0.001).
- 在NSMP亚型中,coP状态与优异的DSS相关 (HR=0.21,p=0.034),ER阳性与更好的PFS相关 (HR=0.13,p=0.037).
- 将coP状态与分期整合在NSMP组中增强了DSS预测 (ΔC指数=+0.082,p<0.05).
结论:
- 结合ER/PR共阳性作为一个强大的独立预测器,在子宫内膜癌中有利的DSS.
- 这种生物标志物组合在与分子分类一起使用时,对具有预后挑战性的NSMP亚型的风险分层进行了改进.
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