在患有多发性硬化症的黑人美国人中,传感运动和默认模式网络的结构功能脱
Emilio Cipriano1, Giacomo Boffa1,2, Maria Petracca3
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
与白人相比,患有多发性硬化症 (MS) 的黑人患者在感觉运动网络 (SMN) 和默认模式网络 (DMN) 中显示出大脑连接的改变. 这项研究揭示了MS的黑人个体在SMN中的结构-功能脱更大,与增加的残疾有关.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 多发性硬化症 (MS) 不成比例地影响黑人个体,导致与非西班牙裔白人个体相比更严重的疾病进展.
- 研究神经网络的变化,特别是感觉运动网络 (SMN) 和默认模式网络 (DMN) 的变化,对于理解多样性障碍患者的残疾差异至关重要.
研究的目的:
- 在MSN和DMN中比较MS (B-PwMS) 的黑人与MS (NHW-PwMS) 的非西班牙裔白人之间的结构性和功能性大脑连接和结构-功能脱.
- 探索网络变化与临床结果 (如身体和认知障碍) 之间的关系.
主要方法:
- 在176名参与者 (B-PwMS,NHW-PwMS,黑人健康对照,NHW-HCs) 中利用了3T-MRI (T1,静止状态功能,扩散成像) 和临床评估 (EDSS,SDMT).
- 使用AAL3图谱分析结构和功能连接,量化全球和本地网络措施.
- 通过关联网络强度,控制人口统计和健康的社会决定因素来计算结构-功能脱.
主要成果:
- 与NHW-PwMS相比,B-PwMS表现出更高的残疾 (EDSS) 和较低的认知功能 (SDMT),受收入和BMI的影响,尽管疾病持续时间,病变负载和大脑体积相似.
- 与对照组相比,B-PwMS和NHW-PwMS都显示SMN和DMN的结构效率降低.
- B-PwMS显示了SMN的显著结构变化和SMN/DMN枢纽的广泛局部重组,以及SMN中更大的结构功能脱,与增加的身体残疾趋势.
结论:
- 尽管疾病负担指标相似,但B-PwMS与NHW-PwMS相比,在SMN和DMN内显示出大脑网络连接的显著改变和更大的结构功能脱.
- 在B-PwMS的SMN中观察到的结构-功能脱与增加的身体残疾有关,突出了MS进展中种族差异的潜在机制.
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