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Updated: Feb 14, 2026

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细菌饮食影响了Pristionchus pacificus中的突变率

Yinan Wang¹, Penghieng Theam¹, Shiela Pearl Quiobe¹

¹Department for integrative Evolutionary Biology, Max Planck Institute for Biology Tübingen, Max-Planck Ring 9, Tübingen, 72076, Germany.

G3 (Bethesda, Md.)

|February 13, 2026

概括

细菌饮食显著影响菌Pristionchus pacificus中的突变积累 (MA) 率. 这项研究揭示了饮食驱动的MA速率变化,而不会改变整体突变谱.

科学领域:

进化生物学是进化的生物学.
遗传学是一个遗传学.
微生物学微生物学

背景情况:

突变积累 (MA) 是一个关键的进化驱动因素,受到环境和遗传因素的影响.
虽然已知温度对突变速率的影响,但饮食的影响,特别是多细胞生物,理解程度较低.

研究的目的:

为了研究不同的细菌饮食如何影响线虫Pristionchus pacificus中的MA率.
在多细胞生物体中的各种细菌饮食中量化MA速率差异.

主要方法:

从 Pristionchus pacificus. 的不同自然分离物中MA线的全基因组测序.
在各种来自自然环境的细菌饮食上培养线虫.
估计单核酸,插入和删除突变率.

主要成果:

平均单核酸突变率在每个基因位点和一代之间从1.69*10^-9到2.23*10^-9不等.
插入和删除率分别在 1.53*10^-10 到 2.90*10^-10 和 3.01*10^-10 到 4.51*10^-10 之间,每个站点每代.
在不同的细菌饮食中的线虫中观察到MA速率的1.4倍差异,突变光谱基本不变.

结论:

细菌饮食是影响 Pristionchus pacificus 中突变积累率的一个重要因素.
饮食对MA发病率的影响发生在没有实质性改变突变谱的情况下.
这些发现突出了饮食在塑造分子层面进化过程中的作用.

关键词:

凯诺哈比迪斯 (Caenorhabditis elegans) 是一个可爱的植物.它们中的一个是Pristionchus pacificus.突变的积累突变的积累饮食影响饮食的影响.突变率的变化率是如何发生的线虫线虫在线虫线虫线虫

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