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相关概念视频

Chromatin Packaging02:21

Chromatin Packaging

22.4K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.4K
Chromatin Packaging01:32

Chromatin Packaging

19.6K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
19.6K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.5K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.6K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.6K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

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VSEPR Theory for Determination of Electron Pair Geometries
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相关实验视频

Updated: Feb 14, 2026

A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
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纳米循环:一个深度学习框架,利用纳米孔测序来预测染色体循环.

Wenjie Huang1, Li Tang1, Matthew C Hill2,3

  • 1School of Computer Science and Engineering, Central South University, Changsha, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 13, 2026
PubMed
概括
此摘要是机器生成的。

使用纳米孔测序数据,NanoLoop可以预测全基因组的染色质相互作用. 这一框架揭示了影响染色体循环和3D基因组组织的甲基化模式,为基因调节提供了新的见解.

关键词:
通过DNA甲基化.染色体循环的染色体循环是什么卷积神经网络 (CNN) 是一种神经网络.表观遗传调节 表观遗传调节纳米孔测序的测序

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Sequencing of mRNA from Whole Blood using Nanopore Sequencing
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科学领域:

  • 基因组学就是基因组学.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 染色体循环对于基因调节和3D基因组结构至关重要.
  • 纳米孔测序提供了同时进行DNA测序和甲基化检测.
  • 了解3D基因组组织是细胞平衡的关键.

研究的目的:

  • 介绍NanoLoop,这是第一个用于从纳米孔数据预测全基因组染色质相互作用的算法框架.
  • 研究DNA甲基化模式在3D基因组组织中的作用.
  • 发现新的染色质循环及其调节关系.

主要方法:

  • 开发了NanoLoop,这是一个使用纳米孔测序数据的算法框架.
  • 将NanoLoop应用于四个人类淋巴细胞细胞系.
  • 分析了染色素循环的甲基化模式.

主要成果:

  • 纳米环实现了优异的预测性能和跨细胞系概括.
  • 在循环中确定了四种不同的甲基化模式,影响了组蛋白修饰和循环类型.
  • 发现了以前未经描述的长距离色素环.

结论:

  • 从纳米孔数据中,NanoLoop有效地预测了色素相互作用.
  • DNA甲基化模式与3D基因组组织和染色质循环形成有关.
  • 提供了对3D基因组表观遗传调节的新见解.