在接受结肠镜检查的便秘患者中比较各种肠道制备方案:随机对照试验的系统审查和网络元分析
Zain Ul Abideen1, Muhammad Hassan Waseem2, Areeba Shoaib3
1King Edward Medical University, Lahore, Pakistan.
概括
对于便秘患者来说,14天的益生菌加酸疗法显著改善了适当的肠道准备 (ABP) 并减少了胀气. 另一种疗法,3L聚乙烯甘醇加上利纳克洛提德,在减少腹痛方面是有效的.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠癌查 结肠直肠癌查
- 药理学 药理学是指药理学的学科.
背景情况:
- 结肠镜对结肠直肠癌的诊断准确性取决于适当的肠道准备 (ABP).
- 经历便秘的患者经常面临标准肠道准备方法的挑战.
- 这项研究评估了专门针对便秘患者的各种肠道制备方案.
研究的目的:
- 进行网络元分析,比较不同肠道制备方案的疗效和安全性.
- 为在接受结肠镜检查的便秘患者确定最佳的肠道准备策略.
- 评估结果,包括适当的肠道准备,胀气,腹痛,恶心和吐.
主要方法:
- 在PubMed,Cochrane Central和ScienceDirect进行了系统的文献搜索,截至2025年4月.
- 使用R软件 (4.3.3版本) 使用"meta"和"netmeta"包进行了频率网络元分析.
- 根据P分数对治疗方案进行排名,以确定最有效和最可容忍的选择.
主要成果:
- 分析包括了15项随机对照试验.
- 14天的益生菌加酸盐 (NaP) 疗法显示了ABP的最高率 (RR=3.59),并且在膨胀方面排名最高 (P-score=0.99).
- 3L聚乙烯甘醇 (PEG) 加上3天的林纳克洛提德 (Lin) 疗法显示,腹痛显著减少 (RR=0.18),并且在疼痛和吐方面排名最高.
结论:
- 14天的益生菌 + NaP和3L PEG + 3天的Lin疗法似乎是非常有效和耐受的肠道准备选择.
- 3L PEG + 3天的林疗法可以提高患者的舒适性和坚持性,因为减少了腹痛.
- 这两种方案都代表了改善便秘患者结肠镜准备的有希望的策略.
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