怀孕期间的尿路感染与早产的时间关系 - - 瑞典一项观察性研究
Karin Dahlquist1,2, Andrea Stuart1,2, Karin Källén2
1Department of Obstetrics and Gynaecology, Helsingborg Hospital, Helsingborg, Sweden.
Acta obstetricia et gynecologica Scandinavica
|February 13, 2026
概括
怀孕期间尿路感染 (UTI) 显著增加了早产风险,特别是当怀孕28周之前诊断时. 诊断后第一周的风险最高,但在整个怀孕期间仍然很高.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 在怀孕期间的传染病.
背景情况:
- 怀孕期间的尿路感染 (UTI) 是早产的已知危险因素.
- 关于UTI诊断的妊娠周如何影响早产风险的数据有限.
研究的目的:
- 调查怀孕期间尿路感染诊断与早产风险之间的关联.
- 分析尿路感染诊断的时间 (妊娠周) 如何影响这种风险.
主要方法:
- 使用瑞典国家登记册 (2014-2020年) 进行的观察性研究,共计684,595例出生.
- 使用ICD-10代码识别出患有尿路感染的孕妇.
- 计算的调整风险比率 (aHR) 为早产,考虑到诊断和妊娠周以来的时间,调整为混因素.
主要成果:
- 在2.8%的孕妇中诊断出尿路感染.
- 在尿路感染诊断和早产之间发现了显著的关联.
- 在UTI诊断后0-6天内观察到的早产的最高调整危险比率 (aHR),根据妊娠周而异 (例如,在22-27周的aHR为18.5).
- 在诊断后的几周内,风险仍然很大,特别是在怀孕早期 (28周前) 诊断的感染.
结论:
- 怀孕期间的尿路感染诊断是早产的重要危险因素.
- 过早分娩风险的严重程度在尿路感染诊断后不久达到最高,并随着时间的推移而下降.
- 这种风险特别高,尤其是在怀孕28周之前诊断出尿路感染时.
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