主体体感官皮质内在活动的变化因果关系地解释了自闭症患者在情感感知方面的差异
Martina Fanghella1,2, Danai Dima1,3, Dimitrios Pinotsis1
1Psychology & Neuroscience Department, School of Health and Medical Sciences, City St George's, University of London, London, UK.
概括
自闭症谱系障碍 (ASD) 处理情绪的困难源于右侧主要体感皮质 (rS1) 内在活动的改变. 这些rS1的变化与alexithymia有关,为ASD神经动态提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 自闭症谱系障碍 (ASD) 与处理情绪的挑战有关.
- 以前的脑电图 (EEG) 研究表明,在ASD中,情绪表达的体现减少了.
- 驱动这些处理差异的特定神经机制仍然不清楚.
研究的目的:
- 为了研究在自闭症患者的情绪处理困难背后的神经动力学.
- 为了确定ASD的减少实施方案是由于体感皮层连接或额叶调节的改变.
- 检查右体感皮质和正面区域在情绪歧视任务中的作用.
主要方法:
- 利用自闭症和典型发育 (TD) 参与者的EEG数据上的动态因果建模 (DCM) (n=38).
- 在一个网络中模拟有效的连接,包括右主 (rS1) 和二次体感皮质,补充运动区域和下额头.
- 在情绪过程中比较神经活动与性别歧视任务.
主要成果:
- 电皮活动中的与任务相关的差异可以通过TD和ASD组的rS1内在活动变化来解释.
- 在TD和ASD组之间观察到这些内在rS1变化的显著差异.
- 个人与任务相关的RS1活动变化与alexithymia特征相关.
结论:
- 对rS1的差异性内在激活与ASD情绪处理困难有因果关系.
- 这些发现强调了体感处理在与自闭症相关的情绪挑战中的作用.
- 亚历克西西米亚似乎调解了ASD中rS1活动和情绪处理之间的关系.
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