来自加拿大西部养场牛的Mycoplasmopsis bovis中的整合性和结合性元素:特征和结合性转移
Sara Andres-Lasheras1, Rahat Zaheer1, Rodrigo Ortega-Polo1
1Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
Frontiers in veterinary science
|February 13, 2026
概括
牛血菌 (Mycoplasma bovis) 是牛慢性呼吸道疾病的关键原因,可以通过称为MICE的移动遗传元素传递抗菌素耐药性基因. 我们在牛中发现了这些元素,这表明了抵抗传播的机制.
科学领域:
- 兽医微生物学 兽医微生物学
- 基因组学就是基因组学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 牛呼吸道疾病 (BRD) 是一个主要的经济问题在料场牛.
- 波维斯菌群是导致慢性BRD的主要病原体,常常对治疗有抗性.
- 菌体中的整合和结合元件 (ICE) 可能会推动抗菌素耐药性的传播.
研究的目的:
- 在Mycoplasmopsis bovis分离物中识别和表征菌质ICE (MICE).
- 评估M. bovis.中的MICE的结合能力.
- 调查MICE的流行情况及其与牛类型和风险因素的关联.
主要方法:
- 来自加拿大料场的124个M. bovis分离物的基因组测序.
- 在体外交配实验中评估M. bovis的结合.
- 循环MICE (cMICE) 的量化作为451个隔离物中结合能力的代理.
主要成果:
- 33.1%的M. bovis分离物具有MICE结合的基因.
- 在实验室条件下,结合发生在10-7-10-8的频率.
- 25.7%的分离物是cMICE阳性的,乳制品牛和肉牛和高风险小牛的患病率更高.
结论:
- 在加拿大料区的M. bovis中存在并能够结合MICE.
- 具有cMICE阳性的M. bovis的流行与牛的来源和健康状况有关.
- 了解MICE动态对于管理牛群中的抗菌素耐药性至关重要.
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