在2型糖尿病中,代谢功能障碍相关的脂肪肝疾病和心血管自主神经病变之间存在关联
Rong Peng1, Yaoyun Ao1, Enni Cen2
1Department of Endocrinology, Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Frontiers in endocrinology
|February 13, 2026
概括
代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与2型糖尿病患者糖尿病心血管自主神经病变 (DCAN) 的风险更高有关. 在MAFLD患者的FIB-4得分较高时,这种风险会增加.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
背景情况:
- 糖尿病心血管自主神经病变 (DCAN) 是2型糖尿病 (T2DM) 的严重并发症.
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 越来越多地被认为是T2DM中显著的并发症.
- 在T2DM患者中,MAFLD和DCAN之间的相互作用需要进一步阐明.
研究的目的:
- 调查MAFLD与DCAN在T2DM患者中流行率之间的关联.
- 确定MAFLD是否可以独立预测T2DM中的DCAN.
- 探索由FIB-4指数表示的肝纤维化对MAFLD-DCAN关系的影响.
主要方法:
- 一项涉及被诊断患有T2DM的患者的横截面研究.
- 基于标准化的心血管自主反射测试 (CARTs) 进行DCAN诊断.
- MAFLD诊断包括脂肪肝和T2DM,不包括其他肝病;FIB-4指数用于评估纤维化风险.
主要成果:
- 全球DCAN的总流行率为30.52%.
- 患有MAFLD的患者与没有MAFLD的患者相比,DCAN的患病率显著更高 (36.49%对21.78%,P=0.013).
- 在多变量调整后,MAFLD仍然是DCAN的独立预测因子 (调整后OR=2.76,P=0.002),与高FIB-4指数相关的风险进一步增加 (调整后OR=2.81,P=0.018).
结论:
- 在T2DM患者中,MAFLD独立地与DCAN的患病率增加有关.
- 在MAFLD患者中,高FIB-4指数的存在进一步增加了DCAN的风险.
- 查MAFLD和评估肝纤维化可能有助于识别T2DM患者的DCAN风险较高.
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