评估直肠癌放射治疗中的轴特定设置错误:基于形束计算机断层扫描的前性研究与身体质量指数相关性
Ainain Yousuf Baba1, Abid Ahmad2, Obair Yousuf Baba3
1Department of Physics, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Journal of medical physics
|February 13, 2026
概括
对直肠癌的精确放射治疗需要特定的规划目标体积 (PTV) 边缘,由每日图像指导提供信息. 体重指数 (BMI) 可以影响设置的准确性,需要个性化的方法.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 放射治疗规划 放射治疗规划
背景情况:
- 图像指导放射治疗 (IGRT) 对于精确瘤向至关重要.
- 准确的患者定位至关重要,以尽量减少对健康组织的辐射剂量.
- 了解设置错误是优化治疗利率的关键.
研究的目的:
- 在接受放射治疗的直肠癌患者中量化设置错误.
- 为了获得最佳的临床目标体积 (CTV) 规划目标体积 (PTV) 利.
- 为了评估身体质量指数 (BMI) 对设置准确性的影响.
主要方法:
- 分析了来自41名直肠癌患者的1102次每日形光束计算机断层扫描 (CBCT) 扫描.
- 测量中侧 (X),尾 (Y) 和前后 (Z) 的转移移位.
- 计算系统 (Σ) 和随机 (σ) 错误,使用范赫克公式来推导PTV保证金.
主要成果:
- 在所有轴 (X:0.04毫米,Y:0.57毫米,Z:0.13毫米) 中观察到的低平均系统设置错误.
- 衍生的PTV利率为7.4毫米 (X),9.1毫米 (Y) 和9.7毫米 (Z).
- 在BMI和Z轴设置错误 (r=0.55,P=0.002) 之间发现了显著的正相关性,其中23.1%的分数需要>5毫米的校正.
结论:
- 由于解剖学变异性,直肠癌放射治疗需要轴特定的PTV边缘.
- 每日CBCT显著提高了设置精度和治疗准确度.
- 建议对BMI等因素进行个性化规划,以获得最佳结果.
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