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在青春期前阶段,贝尔贝林纳米乳液针对大鼠中双甲诱导的毒性
Shahnaz Rajabi1, Atena Mansouri2, Tahora Fakhrtaha3
1Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Toxicology reports
|February 13, 2026
概括
柏柏林纳米乳液 (BNE) 保护幼鼠免受双A (BPA) 的损伤. 10毫克/公斤的BNE剂量逆转了BPA诱导的毒性,减少了氧化应激和炎症.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 双A (BPA) 是一种常见的塑料化学物质,与各种健康问题有关.
- 毒性是与BPA暴露相关的重大问题,特别是在发育阶段.
- 氧化应激和炎症是BPA引起的损伤的关键机制.
研究的目的:
- 为了评估贝贝林纳米乳液 (BNE) 对BPA诱导的毒性在青春期前大鼠的保护作用.
- 调查BNE对BPA引起的损伤的生物化学和病理学标志物的影响.
- 确定BNE的最佳剂量,以减轻BPA引起的毒性.
主要方法:
- 三十六只雄性Wistar大鼠被分为对照组,只有BPA,只有BNE (5和10毫克/公斤) 和BPA+BNE (5和10毫克/公斤) 组.
- 鼠被暴露在BPA (200 mg/kg) 和/或BNE中30天.
- 对脏组织进行了基因病理变化和生物化学标记的分析,包括尿素,肌,BUN,MDA,NO,IL-6,IL-1β,TNF-α,GSH和SOD.
- 计算出估计的膜过率 (eGFR).
主要成果:
- 暴露于BPA显著增加了血清尿素,尿酸,肌,BUN和脏MDA,NO,IL-6,IL-1β和TNF-α水平.
- 在大鼠脏中,BPA暴露降低了eGFR,GSH和SOD活性.
- 10毫克/公斤 (BNE 10) 的柏柏林纳米乳液有效地逆转了这些由BPA引起的变化,将生物化学标记物恢复到接近控制水平.
- 组织病理学检查显示,与BPA + BNE 10组相比,BPA + BNE 10组的管管损伤,炎症减少,质架构改善.
结论:
- 柏柏林纳米乳液 (10毫克/公斤) 显著缓解双A诱导的氧化应激,炎症和在青春期前老鼠的病学损伤.
- BNE显示出抗氧化和抗炎性质,有利于减轻BPA诱导的毒性.
- 这些发现支持BNE在青春期前毒性模型中的安全性和有效性,表明其作为治疗剂的临床研究潜力.
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