案例报告:同时发生的慢性淋巴细胞白血病和宏焦多发性多发性骨髓瘤与外骨髓性血细胞瘤
Yingming Jin1, Shuyan Wang2, Zhi Fang1
1Department of Hematology and Oncology, Ningbo No.2 Hospital, Ningbo, China.
Frontiers in oncology
|February 13, 2026
概括
本病例报告详细介绍了一种罕见的同时出现的慢性淋巴细胞白血病 (CLL) 和宏焦多发性髓瘤 (MFMM) 的罕见病例,呈现为外骨髓性血细胞瘤. 患者实现了对这些血液恶性瘤的初始治疗的完整反应.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床病例报告 临床病例报告
背景情况:
- 同时多发性骨髓瘤 (MM) 和慢性淋巴细胞白血病 (CLL) 是极其罕见的血液恶性瘤.
- 此前没有报道过CLL与宏焦MM (MFMM) 呈现为外骨髓性血细胞瘤 (EMP) 的同时发生.
研究的目的:
- 为了记录一个与EMP并发的CLL和MFMM的独特案例.
- 描述这种罕见的双重诊断的诊断方法和治疗结果.
主要方法:
- 一名67岁的男性出现背部疼痛和白细胞计数升高.
- 诊断工作包括正子发射断层扫描/计算机断层扫描 (PET/CT) 扫描,骨髓吸血和淋巴结活检.
- 病理分析证实了血细胞瘤和瘤B淋巴细胞的透.
主要成果:
- 最终的诊断:宏焦多发性髓瘤 (MFMM) 与慢性淋巴细胞白血病 (CLL) 并发.
- 开始用博尔特佐米布,莱纳利多米德和德克萨米他治疗后,患者完全康复.
- 由于外周感官神经病变,治疗被修改为达拉图穆巴和德克萨米他.
结论:
- 这一案例代表了第一份记录下来的同步CLL和MFMM作为EMP的实例.
- 患者对初始治疗取得了完整的反应,突出了这种罕见疾病的有效治疗策略.
- 成功管理涉及根据治疗出现的不良事件调整治疗,并进行持续的门诊随访.
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