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在低中期风险前列腺癌中,集中低剂量率支臂治疗后的瘤结局
Mohammadmehdi Adhami1,2,3, Jeremy Cheng1,2, Elliot Anderson1,2
1Department of Urology The Alfred Hospital Melbourne Victoria Australia.
BJUI compass
|February 13, 2026
概括
焦点低剂量率支臂治疗显示出对低中期风险前列腺癌的有希望的瘤控制. 平均PSA速度超过0.55 ng/mL/年预测进展,表明需要持续监测.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 辐射瘤学 辐射瘤学
- 在瘤学瘤学.
背景情况:
- 焦点低剂量率 (LDR) 支臂治疗是一种针对局部性前列腺癌 (PCa) 的新兴治疗方法.
- 评估瘤控制和进展预测因子对于完善焦点LDR支臂治疗方案至关重要.
研究的目的:
- 为了前性地评估低中期风险PCa的焦点LDR支臂治疗后的瘤控制和病态进展.
- 为了确定这种治疗方式后病理进展的预测因素.
主要方法:
- 为接受焦点LDR支臂治疗的患者建立了一个前性的多中心临床注册表 (LIBERATE).
- 随访包括连续PSA测量,mpMRI和18-24个月的跨关节前列腺活检.
- 病理控制被定义为在重复活检时没有癌症或低度疾病;进展被定义为没有变化或瘤升级.
主要成果:
- 在55名完成评估的患者中 (平均随访时间为38个月),76.4%的患者实现了病理控制.
- 病理进展发生在23.6%的患者中,5.5%的患者经历了临床显著的进展.
- 平均PSA速度>0.55 ng/mL/年强烈预测了病理进展 (OR 23.54,p=0.001).
结论:
- 焦点LDR支臂疗法证明,在一些具有低中等风险,可见于成像前列腺癌的患者中,可以对癌症进行令人满意的控制.
- 平均PSA速度是病理进展的重要预测指标.
- 长期的瘤结果需要进一步评估,并进行延长的随访.
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