精子DNA碎片化对胚胎裂变和精液参数在体外受精治疗中的影响
Yu-Li Chuang1, Hsiao-Chin Huang1, Cheng-Hsuan Wu2
1Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan, cch.org.tw.
Journal of aging research
|February 13, 2026
概括
高精子DNA碎片化 (SDF) 对体外受精 (IVF) 的结果产生负面影响,导致受精率和裂变率降低. 高SDF与精子质量降低和流产风险增加有关,这突显了其在男性生育能力评估中的重要性.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 胚胎学 胚胎学
背景情况:
- 精子DNA碎片化 (SDF) 是影响男性生育能力和体外受精 (IVF) 成功的潜在因素.
- 了解SDF,胚胎发育和精液参数之间的相关性对于优化辅助生殖疗法至关重要.
研究的目的:
- 研究在接受试管婴儿治疗的夫妇中SDF和胚胎发育之间的关系.
- 检查SDF水平与各种精液参数之间的相关性.
主要方法:
- 一项对52对接受试管婴儿的夫妇的回顾性研究,SDF使用TUNEL试验进行评估.
- 根据SDF比率 (<20%和≥20%),夫妇被分为两组.
- 统计分析包括胚胎发育的奇平方测试和精液参数的t测试.
主要成果:
- 在高SDF组 (≥20%) 中观察到明显较低的受精率 (68.88%对比78.62%) 和裂解率 (37.35%对比57.89%).
- 高SDF组表现出明显增加的流产率 (14.29%对6.25%).
- 较低的精液度,精子运动性和渐进性运动性与较高的SDF水平有显著的关联.
结论:
- SDF显著影响早期胚胎发育,导致受精和裂解率降低.
- 高SDF与精子质量下降和胚胎移植后流产风险增加有关.
- SDF测试是评估男性生育能力的宝贵工具,特别是对于有反复IVF失败史的夫妇.
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