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Updated: Feb 14, 2026

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基于的可变形纳米药物,用于增强瘤特异化疗

Pengcheng Li1, Jun Tao2,3, Xinzeyu Yi1

  • 1Department of Orthopedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University Wuhan 430071 P. R. China yiwanrong@whu.edu.cn.

RSC advances
|February 13, 2026
PubMed
概括

研究人员开发了对谷氨敏感的可变形基纳米药物 (DMN),以克服改善化疗的生物障碍. 这些DMN增强了骨髓瘤瘤中的药物输送和积累,显示了针对癌症治疗的重大潜力.

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Plastic Deformations

Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
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Plastic Deformations01:14

Plastic Deformations

It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
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Dose-Response Relationship: Selectivity and Specificity

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
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Deformations in a Symmetric Member in Bending01:18

Deformations in a Symmetric Member in Bending

When analyzing the deformation of a symmetric prismatic member subjected to bending by equal and opposite couples, it becomes clear that as the member bends, the originally straight lines on its wider faces curve into circular arcs, with a constant radius centered at a point known as Point C. This phenomenon helps to understand the stress and strain distribution within the member more clearly.
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Deformation of Member under Multiple Loadings

When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
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