生物®对微生物生物膜的活性
Amy V Mundanchira1,2, Agnes Wong1,2, Kristen Klos-Maki3
1Department of Biological Sciences, Binghamton University, Binghamton, NY, United States.
Frontiers in antibiotics
|February 13, 2026
概括
植物补充剂Biocidin®显著减少了微生物生物膜和浮游生物细胞. 它在较高度下显示了生物膜消灭,显示了治疗生物膜相关感染的潜力.
科学领域:
- 微生物学 微生物学
- 自然产品化学 自然产品化学
- 传染性疾病 传染性疾病
背景情况:
- 生物膜是环境中普遍存在的微生物群落,作为微生物群的一部分,为人类健康做出贡献或引起疾病.
- 抗微生物耐受性和耐药性是治疗生物膜相关感染的重大挑战,推动了寻找替代疗法的研究.
- 植物提取物越来越多地被探索为潜在的抗微生物剂,这是由于广泛的抗微生物耐药性.
研究的目的:
- 评估植物补充剂Biocidin®对常见病原性微生物生物膜的疗效.
- 确定单剂量和连续剂量Biocidine®暴露对生物膜和浮游生物微生物群体的影响.
- 评估Biocidin®的亚抑制度对生物膜活性的影响.
主要方法:
- 测试了Biocidin®对*大肠杆菌*,金黄色葡萄球菌*,假菌*,肺炎菌和白菌的生物膜进行了测试.
- 服用单剂量 (玻尿酸) 和24小时连续剂量的Biocidin®,其度各不相同 (25%和50%).
- 生物膜和浮游生物种群的量化减少和评估的生物膜根除.
主要成果:
- 一次剂量Biocidin®显著减少了生物膜和浮游生物微生物种群的2 Log以上.
- 持续暴露于25%和50%的Biocidin®显示出双相杀伤曲线.
- 50%的Biocidin®度实现了对*P. aeruginosa*,*S. aureus*和*E. coli*的完整生物膜根除.
- 微抑制度的Biocidin®并没有影响生物膜活力.
结论:
- 比奥西丁®对关键的致病生物膜表现出强大的抗菌活性.
- 这种植物补充剂显示出作为治疗生物膜相关感染的治疗剂的前景.
- 生物可以作为一种有价值的补充物,用于自然医学的感染控制方法.
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