维多利祖马布扩展接入计划跨国研究的最终结果表明,长期治疗持久性和安全性
Silvio Danese1, Milan Lukáš2, Miroslava Volfová3
1Department of Gastroenterology and Endoscopy, University Vita-Salute, San Raffaele, Milan, Italy.
Therapeutic advances in gastroenterology
|February 13, 2026
概括
维多利祖马布 (抗α4β7整合素) 在性结肠炎和克罗恩氏病中显示出高治疗持久性和安全性.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 维多利祖马布是一种针对α4β7整体的肠选择性抗体,用于性结肠炎 (UC) 和克罗恩病 (CD).
- 评估vedolizumab的长期持久性和安全性对于管理慢性炎症性肠道疾病至关重要.
研究的目的:
- 评估vedolizumab在UC和CD患者的长期治疗持久性和安全性.
- 在临床试验后,在扩展访问计划中评估vedolizumab的疗效和耐受性.
主要方法:
- 一项前性,跨国,IIIb/IV期研究 (NCT02743806) 涉及331名UC/CD的成年患者.
- 患者在延长访问计划 (XAP) 中,每8周 (Q8W) 或每4周 (Q4W) 继续服用维多利祖马布300毫克静脉注射.
- 从2016年8月到2023年1月收集的数据,重点关注治疗持续性,剂量,不良事件和严重不良事件 (SAE).
主要成果:
- 观察到高持续率:98%的UC和95%的CD在6个月后没有复发的Q8W剂量.
- 严重不良事件率低 (13%UC,16%CD) 和严重感染率低 (1%UC,2%CD);没有与治疗相关.
- 在XAP中平均治疗持续时间为3.5年 (UC) 和3.6年 (CD),再升级率低至Q4W剂量.
结论:
- 用于Q8W的维多利祖马布显示了高治疗持久性和UC和CD患者的良好的安全概况.
- 低复发率和剂量升级表明在长期治疗中持续有效性和耐受性.
更多相关视频
08:51Author Spotlight: Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model
Published on: March 31, 2023
5.5K
07:07Controlled-release of Chlorine Dioxide in a Perforated Packaging System to Extend the Storage Life and Improve the Safety of Grape Tomatoes
Published on: April 7, 2017
11.6K
相关概念视频
Survey Safety
419
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
419
Long-term Depression
33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Long-term Depression
3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.4K
Household Wiring And Electrical Safety
1.7K
Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K
Gravitational Potential Energy for Extended Objects
2.0K
Consider a system comprising several point masses. The coordinates of the center of mass for this system can be expressed as the summation of the product of each mass and its position vector divided by the total mass:
2.0K
Long-term Potentiation
58.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.8K
