2014年至2024年间克洛扎使用的全球趋势:一项纵向流行病学研究,采用来自75个国家的数据
Ita Fitzgerald1,2,3, Sarah O'Dwyer4, Ciara Ní Dhubhlaing1,2,3
1Pharmacy Department, St Patrick's Mental Health Services, Dublin, Ireland.
The Lancet regional health. Europe
|February 13, 2026
概括
对治疗耐药精神分裂症的克洛扎宾的使用在全球范围内正在增加,但在各国之间存在显著差异. 需要超越宽松监测的策略来促进克洛扎的利用率.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 克洛扎在治疗耐药精神分裂症中的不足使用是全球公共卫生问题.
- 调查国际西使用趋势对于应对这一挑战至关重要.
研究的目的:
- 分析75个国家的克洛扎使用的当代趋势.
- 为了确定与克洛扎使用变化相关的因素.
主要方法:
- 利用国家处方数据库和全球药品销售数据 (IQVIA).
- 从2014年到2024年,计算出使用克洛扎的全国年均流行率 (DDD/1000人/天).
- 采用线性回归来测试时间趋势,并探索精神病医生的数量和监测严格性作为预测因素.
主要成果:
- 在2024年,全球平均克洛扎使用量达到0.46 DDD/1000居民/天,但存在显著差异 (例如,新西兰2.99,新加坡0.0007).
- 在研究期间,全世界的克洛扎使用量增加了0.13DDD/1000人/天.
- 较高的精神病医生数量与克洛扎使用量的增加相关,而监测严格性则没有.
结论:
- 尽管全球使用量有所增加,但克洛扎使用量在各国之间仍然存在很大差异.
- 监测严格度和利用率之间缺乏关联表明,政策和实践的变化超越监测是必要的,以系统地提高克洛沙的使用.
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