空间多组学揭示了结合小细胞肺癌中的单克隆起源,神经内分泌可塑性和微环境
bioRxiv : the preprint server for biology
|February 13, 2026
概括
联合小细胞肺癌 (cSCLC) 呈现混合组织学和攻击性行为. 这项研究揭示了共同的起源和独特的瘤领域,突出了血统可塑性,并为cSCLC提供了新的诊断试验.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 癌症生物学 癌症生物学
背景情况:
- 结合性小细胞肺癌 (cSCLC) 是一种罕见的,具有混合SCLC和NSCLC/LCNEC组织学的侵袭性亚型.
- 目前的临床管理将cSCLC视为纯SCLC,因为对其生物学,可塑性和瘤微环境 (TME) 的理解有限.
研究的目的:
- 对未经治疗的cSCLC进行多组学分析,以阐明其生物学,血统可塑性和TME.
- 开发用于cSCLC检测的改进诊断工具.
主要方法:
- 在19个未经治疗的cSCLC瘤上进行多omics分析,包括空间解析的全外体序列 (WES),空间转录组学 (ST) 和单核RNA序列 (snRNA-seq).
- 对瘤领域,TME组成,免疫景观和纤维细胞亚型的分析.
- 开发和验证cSCLC检测仪试验.
主要成果:
- SCLC和NSCLC/LCNEC组件具有单克隆起源,具有不同的突变和副本数量改变模式.
- 确定了具有独特TME和免疫景观的空间明显的瘤领域.
- 观察到广泛的谱系可塑性,包括LUAD到SCLC的转差和SCLC亚型的共存.
- 域边界的纤维细胞丰富区域可能会影响TME和治疗反应.
结论:
- cSCLC表现出显著的谱系可塑性和复杂的TME相互作用,偏离纯SCLC生物学.
- 这些发现需要针对cSCLC定制的治疗策略和先进的诊断框架.
- 开发的cSCLC检测仪测定提高了在组织和液体活检中的检测.
更多相关视频
12:04Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
29.5K
06:05Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
Published on: June 2, 2023
10.1K
相关概念视频
Ecological Niches
26.8K
All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.
26.8K
Cancers Originate from Somatic Mutations in a Single Cell
15.0K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.0K
Stem Cell Niche
6.4K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.4K
Multipotency and Niche of Bulge Stem Cell
4.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.3K
Plasticity
3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
Plasticizers
378
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
378
