PTEN和p53的表达以及它们在乳腺癌中的临床病理相关性
Tonushree Purohit1, Soumya Sahu1, Manasi Dandekar2
1Department of Pathology, People's College of Medical Sciences and Research Centre, Bhopal, IND.
Cureus
|February 13, 2026
概括
失去PTEN和过度表达p53在乳腺癌中很常见,与侵略性特征有关. 评估这两种生物标志物可能有助于乳腺癌患者的预后和治疗决策.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
背景情况:
- 乳腺癌是妇女死亡的主要原因之一.
- 像PTEN和p53这样的瘤抑制基因会影响癌症行为.
- 调查PTEN和p53表达对于了解乳腺癌预后至关重要.
研究的目的:
- 在乳腺癌中评估PTEN和p53的免疫组织化学表达.
- 分析PTEN和p53表达和临床病理参数之间的关联.
主要方法:
- 对50名女性乳腺癌病例进行横截面研究.
- 免疫组织化学 (IHC) 用于评估PTEN和p53表达.
- 进行统计分析以确定关联.
主要成果:
- 大多数情况下观察到PTEN表达的丧失,与较高的瘤等级和淋巴结转移有关.
- 在大多数情况下,p53过度表达,趋势与较高的瘤等级,绝经前状态和淋巴结阳性.
- 在PTEN损失和p53阳性之间发现了反向关系.
结论:
- 在乳腺癌中,PTEN损失和p53过度表达是常见的.
- 这些变化与瘤的攻击性特征相关.
- 对PTEN和p53的联合评估可能提供预后价值并指导乳腺癌治疗.
更多相关视频
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
9.6K
06:29Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
Published on: June 7, 2019
13.4K
相关概念视频
Correlations
36.6K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.6K
Correlation and Causation
43.0K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
43.0K
Correlation
15.2K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
15.2K
Correlation and Regression
3.5K
In statistics, correlation describes the degree of association between two variables. In the subfield of linear regression, correlation is mathematically expressed by the correlation coefficient, which describes the strength and direction of the relationship between two variables. The coefficient is symbolically represented by 'r' and ranges from -1 to +1. A positive value indicates a positive correlation where the two variables move in the same direction. A negative value suggests a...
3.5K
Coefficient of Correlation
8.7K
The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable x and the dependent variable y.
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
8.7K
Correlation of Experimental Data
491
Dimensional analysis simplifies complex physical problems and guides experimental investigations, but it does not provide complete solutions. It identifies the dimensionless groups that influence a phenomenon, but experimental data is needed to establish the specific relationships and validate theoretical predictions.
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
491
