在神经外科手术中对焦激光内显微镜的临床应用:一个范围审查
Yuan Xu1, Carlos E Calderon-Valero1, Thomas J On1
1The Loyal and Edith Davis Neurosurgical Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Frontiers in surgery
|February 13, 2026
概括
同焦激光内分显微镜 (CLE) 在手术期间提供快速的实时脑瘤可视化. 这种光学活检工具的诊断准确度与冷部位相当,有助于神经外科手术.
科学领域:
- 神经外科 神经外科
- 医疗成像医学成像
- 病理学 病理学 病理学
背景情况:
- 聚焦激光内分显微镜 (CLE) 是一种新兴的手术内工具,用于实时,细胞分辨率可视化脑瘤的组织架构.
- 它有可能通过提供快速的手术内反来补充冷部位病理学.
研究的目的:
- 进行前性临床研究的范围审查.
- 描述CLE平台,光体,手术应用和神经外科患者的诊断性能.
主要方法:
- 遵循PRISMA-ScR指南进行PubMed,Scopus和Embase的系统搜索.
- 包括神经外科患者手术内CLE成像的前性临床研究.
- 提取了关于研究设计,CLE系统,光剂使用,病理类型,诊断性能和工作流程的数据.
主要成果:
- 19项研究符合纳入标准,其中63%是在过去五年发表的.
- 研究了五个CLE平台,其中CONVIVO是最常见的 (47%).
- CLE的诊断准确度与冷截面相当 (灵敏度高达93%,特异性高达94%) 并更快.
结论:
- 临床证据支持CLE在神经外科快速手术内组织学中的可行性,安全性和效率.
- 目前的研究是观察性的,需要进行干预性试验,以确定CLE在指导瘤切除和改善患者治疗结果方面的作用.
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