相关实验视频
Updated: Jul 19, 2026

09:41
Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
Published on: June 17, 2014
概括
这项研究纠正了上一篇文章的DOI. 修正后的DOI确保了正确的引用和访问研究结果,以准确的科学引用.
科学领域:
- 图书统计学 图书统计学
- 科学出版科学出版
背景情况:
- 准确的引用对于科学完整性至关重要.
- 数字物体识别器 (DOI) 对于链接研究出版物至关重要.
研究的目的:
- 纠正以前发表的文章的数字物体标识符 (DOI).
- 确保科学工作的准确引用和可访问性.
主要方法:
- 在原始出版物中错误的DOI的识别.
- 发出一个纠正通知与准确的DOI.
主要成果:
- 这篇文章的DOI已被纠正为10.1159/000547402.
- 校正有助于对研究进行正确的引用和检索.
结论:
- 纠正DOI对于保持学术记录至关重要.
- 确保DOI准确性有助于科学研究的可复制性和影响.
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Mismatch Repair
Overview
Proofreading
Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Proofreading
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Errors During Replication are Corrected by the DNA Polymerase Enzyme
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
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