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Updated: Feb 14, 2026

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生物活性陶加工水调节肠道微生物群和肝脏AMPK激活 SMP30 淘汰赛小鼠
Dong-Hun Kim1, Soo-Nyun Choi2, Kyongman An3
1Groundwater Environment Research Center, Geo-Environment Research Division, Korea Institute of Geoscience and Mineral Resources, Korea, Republic of.
Gut microbiome (Cambridge, England)
|February 13, 2026
概括
生物活性陶加工水 (BCP) 可以通过积极影响肠道微生物和老年小鼠的肝脏代谢来促进健康的衰老. 这表明BCP是潜在的饮食干预与年龄相关的衰退.
科学领域:
- 老年学和营养科学研究
- 微生物组研究 微生物组研究
- 代谢健康 代谢健康
背景情况:
- 人口老龄化需要有效的策略来增加健康的寿命和预防与年龄相关的疾病.
- 老化标记蛋白30淘汰赛 (SMP30 KO) 小鼠模型表现出加速衰老,并模仿人类维生素C缺乏.
- 研究新的饮食干预措施对于减轻与年龄相关的健康问题至关重要.
研究的目的:
- 研究生物活性陶加工水 (BCP) 对肠道微生物群落和老年小鼠肝脏代谢的影响.
- 为了比较BCP与天然矿泉水 (MW) 和补充维生素C (MW-vitC) 的MW.
- 探索BCP作为健康衰老的饮食干预措施的潜力.
主要方法:
- 利用SMP30 KO小鼠作为加速衰老和维生素C缺乏症的模型.
- 给不同小鼠群组使用了BCP,MW和MW-vitC.
- 分析了肠道微生物群落 (描述性趋势) 和肝脏代谢.
- 使用PICRUSt2进行微生物群落的功能分析.
主要成果:
- BCP的使用与肠道微生物群的变化有关,增加了像Akkermansia和Lactobacillus这样有益的属.
- 功能分析表明,二次代谢物生物合成,维生素代谢和异生物生物生物降解的途径中的丰富.
- 与对照组相比,BCP显著增加了激活的肝脏AMP激活蛋白激酶 (AMPK) 水平.
结论:
- 在老年小鼠中,BCP在调节肠道微生物群组成和功能方面显示出潜力.
- BCP可能会影响关键的代谢途径,通过肝脏AMPK激活的增加来表明.
- 这些发现表明BCP是一种潜在的饮食干预措施,以支持健康的衰老和减轻代谢下降.
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