用体积调节弧线疗法对儿童进行肌肉整体辐射 - - 一个单一的中心体验
Hoong Hoong Ng1, Munira Mohd Rejab1,2, David Lee1,3
1Department of Clinical Oncology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.
Advances in radiation oncology
|February 13, 2026
概括
体积调节弧线疗法-全身辐射 (VMAT-TBI) 是为接受干细胞移植的儿科急性淋巴细胞白血病患者提供安全有效的调节方案. 这种方法表明了良好的目标覆盖率和可接受的毒性,支持其在各种环境中的使用.
科学领域:
- 辐射瘤学 辐射瘤学
- 儿科血液瘤学
- 干细胞移植 干细胞移植
背景情况:
- 全身辐射 (TBI) 是儿童急性淋巴细胞白血病 (ALL) 条件治疗的重要组成部分,在全源造血干细胞移植 (HSCT) 之前.
- 实现了体积调制弧线疗法-TBI (VMAT-TBI),以提高TBI交付中的目标合规性和风险器官节省.
- 这项研究评估了儿童患者在VMAT-TBI的初始机构经验.
研究的目的:
- 评估VMAT-TBI在儿童ALL患者中的可行性和有效性.
- 分析VMAT-TBI的治疗计划和治疗指标.
- 评估与VMAT-TBI相关的早期临床结果和急性毒性.
主要方法:
- 在2023年10月至2025年6月期间,对10名接受VMAT-TBI治疗的儿科患者进行了回顾性审查.
- 患者接受了3天内6个小部分的12 Gy,随后接受了etoposide.
- 收集的数据包括治疗计划参数,分娩时间,生存率和急性毒性.
主要成果:
- VMAT-TBI计划实现了优异的目标覆盖率 (V100>90%),并满足了风险器官剂量限制 (例如,平均肺剂量为8.8 Gy).
- 平均光束启动时间为每小部分21.3分钟,图像引导证实精度在3毫米和<1度旋转范围内.
- 一年总生存率和无复发生存率为90%,非复发死亡率为10%. 粘膜炎 (70%) 和胃肠道毒性 (50%的吐,40%的腹) 是最常见的急性毒性.
结论:
- VMAT-TBI是一种安全,可行和有效的治疗方式,用于接受HSCT的儿科ALL患者.
- 该技术提供了强大的目标覆盖范围和可接受的急性毒性概况.
- 这些发现支持VMAT-TBI的实施,即使在资源有限的环境中.
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