炎症性肠病和所有引起或特定骨折的风险:一个元流行病学研究
Weiren Wang1, Hongfei Liu2, Wei Wei3
1The First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Frontiers in endocrinology
|February 13, 2026
概括
患有炎症性肠病 (IBD) 的人面临13%更高的骨折风险. 对于某些特定部位,如下肢和克罗恩氏病患者,这种风险增加,需要对骨健康进行监测.
科学领域:
- 胃肠病学和肝病学
- 风湿病学和整形外科
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 包括诸如克罗恩病和性结肠炎等慢性疾病.
- IBD与系统性并发症有关,包括对骨健康的潜在影响.
- 在IBD患者中,骨折风险需要在不同解剖部位进行全面评估.
研究的目的:
- 在IBD患者中进行骨折风险的元流行病学分析.
- 用现有队列研究数据评估整体和特定地点的骨折风险.
- 综合证据,为有关IBD骨健康的临床管理策略提供信息.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,遵循PRISMA 2020指南.
- 包括报告IBD患者骨折的相对风险 (RR) 和95%置信区间 (CI) 的队列研究.
- 进行了随机效应元分析,敏感性分析,子组分析和出版偏差评估.
主要成果:
- 分析了11项涉及超过54,000名IBD患者的队列研究,研究质量中等至高.
- 在IBD患者中观察到13%的全因骨折风险增加 (RR=1.13,95%CI:1.03-1.24)
- 发现肋骨,部,上肢和下肢骨折的风险明显更高,下肢骨折的风险最高 (RR=1.60). 克罗恩氏病患者的风险比性结肠炎患者高.
结论:
- 炎症性肠病与整体和特定部位骨折风险的显著增加有关.
- 这些发现凸显了克罗恩病患者和下肢骨折中骨折风险的增加.
- 有针对性的骨健康监测对于有效管理IBD患者至关重要.
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