在乳头甲状腺癌中标准化宫淋巴结评价:超声波节点-RADS的诊断准确性
Hongjun Zhang1, Danni He1, Muyi Mao1
1Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Frontiers in endocrinology
|February 13, 2026
概括
节点-RADS系统在检测皮质甲状腺癌中的宫淋巴结转移中显示了中度的准确性. 将Node-RADS与外围血管性结合起来,可以显著提高手术前评估的诊断性能.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 病理学 病理学 病理学
背景情况:
- 乳头甲状腺癌 (PTC) 经常转移到宫淋巴结 (LNs).
- 准确的手术前评估LN转移对于手术规划和患者管理至关重要.
- 目前用于评估宫LNs的超声波特征在诊断性能方面存在限制.
研究的目的:
- 评估节点报告和数据系统 (Node-RADS) 在PTC中宫LN转移的诊断性能.
- 将Node-RADS与常规可疑的超声波特征进行比较.
- 评估将Node-RADS与外围血管性集成的附加值.
主要方法:
- 对227名PTC患者 (269名LNs) 的回顾性分析,进行了手术前超声波和活检.
- 两个放射科医生使用Node-RADS (1-5) 来独立评分LNs.
- 使用ROC分析对节点-RADS性能与其病理学和ATA定义的可疑特征进行比较.
主要成果:
- 转移性LNs显示了更高的Node-RADS得分,恶性瘤率从35.7% (得分1) 增加到88.2% (得分5).
- 节点-RADS实现了0.720的AUC,超过了个别可疑特征 (最好的AUC为外周血管性0.703).
- 结合Node-RADS和外周血管性的综合模型显著改善了诊断性能 (AUC 0.825,p < 0.01).
结论:
- 节点-RADS提供了标准化,可重现的风险分层,用于宫LN转移在PTC中,准确度中等.
- 将Node-RADS与外周血管系统集成,可以提高诊断性能.
- 节点-RADS系统显示了在PTC中宫LN转移的术前评估的潜在临床实用性.
相关概念视频
01:23Detailed Structure and Function of Lymph Nodes
5.1K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
5.1K
01:14Node Analysis for AC Circuits
684
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
684
01:11Papillary Dermis
5.9K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.9K
02:07Improving Translational Accuracy
15.0K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
15.0K
01:30Heart Failure IV: Classification and Diagnostic Evaluation
429
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
429
03:37Uncertainty in Measurement: Accuracy and Precision
105.2K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.
105.2K