素受体rs1137101多态性和改变的素-sOb-R轴有助于古吉拉特州人口的2型糖尿病风险
Nishant Parmar1, Nirali Rathwa1, Roma Patel1
1Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
Frontiers in endocrinology
|February 13, 2026
概括
在古吉拉特州的人群中,LEPR rs1137101 A/G多态性与2型糖尿病 (T2D) 的风险增加有关. 这种遗传变异,以及改变的瘦素和可溶性瘦素受体水平,可能会导致T2D易感性.
科学领域:
- 遗传学 是一个遗传学.
- 代谢疾病 代谢疾病
- 内分泌学 在内分泌学.
背景情况:
- 瘦素 (LEP) 和它的受体 (LEPR) 调节身体体重和新陈代谢.
- 在LEP和LEPR的遗传变异与2型糖尿病 (T2D) 有关.
- LEPR rs1137101 A/G 多态性是代谢风险的潜在决定因素.
研究的目的:
- 调查古吉拉特州人口中LEP和LEPR遗传变异与T2D的关联.
- 分析基因型-表型与代谢参数的相关性.
- 评估与T2D相关的LEP和LEPR的转录和蛋白质水平.
主要方法:
- 使用PCR-RFLP进行LEP (rs7799039,rs2167270) 和LEPR (rs1137101,rs1805094) 多态的基因定型.
- 通过qPCR量化LEP和LEPR转录水平.
- 使用ELISA测量血瘦素和可溶性瘦素受体 (sOb-R) 蛋白水平.
- 评估代谢参数,包括BMI,FBG和脂质概况.
主要成果:
- 在LEPR rs1137101 A/G多态,特别是GG基因型和G等位基因,显示了与增加T2D风险的显著关联.
- GG基因型与高的空腹血糖 (FBG) 和总胆固醇 (TC) 水平相关.
- 二型糖尿病患者的LEP转录/蛋白质增加,LEPR转录/蛋白质水平降低.
- 莱普和sOb-R蛋白水平与BMI和甘油三 (TG) 水平呈正相关.
结论:
- LEPR rs1137101 A/G多态性与古吉拉特州人口中T2D易感性增加有关.
- 升高的瘦素和降低的溶性瘦素受体 (sOb-R) 蛋白水平可能会导致T2D风险.
- 基因型-表型相关性突出显示了这些遗传和分子因素在代谢健康中的作用.
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