来自Abelmoschus manihot (L.) 的总黄素通过调节肠轴来改善糖尿病病症
Hongmei Yu1, Yuanxin Liu2, Harvest F Gu1,3
1College of Pharmacy, Qilu Medical University, Zibo, China.
Frontiers in medicine
|February 13, 2026
概括
来自Abelmoschus manihot (TFA) 的全类黄素通过改变肠道细菌,代谢物和基因通路来治疗糖尿病病 (DN). 这突显了肠-轴作为DN的关键治疗点.
科学领域:
- 药理学和病学 药理学和病学
- 肠道微生物组研究研究
- 代谢学和转录学.
背景情况:
- 含有来自Abelmoschus manihot (TFA) 的全方位黄素的Huangkui囊在治疗糖尿病病 (DN) 的2型糖尿病 (T2D) 中表现有前途.
- 之前的临床研究表明,TFA与伊尔贝沙坦结合是一种有效的治疗T2D患者经历DN.
研究的目的:
- 研究TFA在糖尿病病 (DN) 的治疗机制.
- 阐明TFA如何调节肠轴在DN的背景下.
主要方法:
- 给db/db小鼠使用TFA,irbesartan或载体.
- 通过ELISA测量尿动白蛋白-肌素比率 (UACR).
- 使用16S rRNA测序对肠道细菌组成的分析.
- 血清代谢物的量化通过LC-ESI-MS/MS.
- 使用IlluminaRNA测序对脏转录组的评估.
主要成果:
- 使用TFA显著降低了UACR和改变了肠道菌群,增加了有益的细菌 (例如,Dietzia,Faecium),减少了有害的细菌.
- 血清代谢分析显示,TFA增加了切丁3-葡萄糖和n-cinnamyl甘氨酸,同时降低了皮质醇水平.
- 脏转录组显示TFA下调基因参与中性粒细胞外细胞陷形成,类固醇激素生物合成和皮质醇合成/分泌.
结论:
- 通过调节肠轴,TFA减轻了糖尿病病 (DN) 的进展.
- 关键机制包括改变肠道菌群,调节循环中的代谢物,抑制特定的基因活性通路.
- 肠-轴代表了TFA在DN管理中的重要治疗目标.
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